Atopic dermatitis (AD) is a common skin inflammatory disease characterized by the
production of thymic stromal lymphopoietin (TSLP) and marked TH2 polarization. Recent …

Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic
dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably …

Background Epidermal barrier dysfunction has been recognized as a critical factor in the
initiation and exacerbation of skin inflammation, particularly in patients with atopic dermatitis …

Skin fibrotic remodeling is a major feature in human atopic dermatitis (AD). Inflammation and
tissue fibrosis are common consequences of Th2 responses. Elevated IL-13 and thymic …

Keratinocytes constitute the first‐line barrier against exogenous antigens and contain Toll‐
like receptors (TLRs), which function as pattern‐recognition molecules to activate …

David Margolis is a consultant for Pfizer, Leo, and Sanofi with respect to studies of atopic
dermatitis and serves on an advisory board for the National Eczema Association. Joy Wan …

In the skin lesions of atopic dermatitis (AD), keratinocytes release large quantities of thymic
stromal lymphopoietin (TSLP), causing unfavorable inflammation along with skin damage …

Genetic or vitamin D3‐induced overexpression of thymic stromal lymphopoietin (TSLP) by
keratinocytes results in an atopic dermatitis (AD)‐like inflammatory phenotype in mice …

Background Thymic stromal lymphopoietin (TSLP) mediates proallergic T helper 2‐type
responses by acting on leucocytes. Endogenous pathways regulating TSLP production are …

Elevated T-helper type 2 cytokines in atopic skin, such as IL-4 and IL-13, were thought to be
responsible for an impaired expression of antimicrobial proteins, which may contribute to the …