A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics
SL Weekes, B Barker, S Bober, K Cisneros… - Bulletin of mathematical …, 2014 - Springer
Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying
proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer …
proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer …
A mathematical model of average dynamics in a stem cell hierarchy suggests the combinatorial targeting of cancer stem cells and progenitor cells as a potential …
R Molina-Peña, JC Tudon-Martinez… - Cancers, 2020 - mdpi.com
Simple Summary Cancer stem cell (CSC) directed therapies have been increasingly
developed during the last years. However, some reported experiments using this strategy …
developed during the last years. However, some reported experiments using this strategy …
Stochastic dynamics of hematopoietic tumor stem cells
D Dingli, A Traulsen, JM Pacheco - Cell cycle, 2007 - Taylor & Francis
Many tumors derive from the transformation of normal stem cells into cancer stem-cells that
retain their self-renewal capacity. This modern view of cancer has provided a natural …
retain their self-renewal capacity. This modern view of cancer has provided a natural …
Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity
The recently developed concept of cancer stem cells (CSC) sheds new light on various
aspects of tumor growth and progression. Here, we present a mathematical model of …
aspects of tumor growth and progression. Here, we present a mathematical model of …
A mathematical-biological joint effort to investigate the tumor-initiating ability of cancer stem cells
The involvement of Cancer Stem Cells (CSCs) in tumor progression and tumor recurrence is
one of the most studied subjects in current cancer research. The CSC hypothesis states that …
one of the most studied subjects in current cancer research. The CSC hypothesis states that …
A simple mathematical model based on the cancer stem cell hypothesis suggests kinetic commonalities in solid tumor growth
R Molina-Peña, MM Álvarez - PloS one, 2012 - journals.plos.org
Background The Cancer Stem Cell (CSC) hypothesis has gained credibility within the
cancer research community. According to this hypothesis, a small subpopulation of cells …
cancer research community. According to this hypothesis, a small subpopulation of cells …
Replicator dynamics of cancer stem cell: Selection in the presence of differentiation and plasticity
K Kaveh, M Kohandel, S Sivaloganathan - Mathematical biosciences, 2016 - Elsevier
The cancer stem cell hypothesis has evolved into one of the most important paradigms in
cancer research. According to cancer stem cell hypothesis, somatic mutations in a …
cancer research. According to cancer stem cell hypothesis, somatic mutations in a …
The tumor growth paradox and immune system-mediated selection for cancer stem cells
T Hillen, H Enderling, P Hahnfeldt - Bulletin of mathematical biology, 2013 - Springer
Cancer stem cells (CSCs) drive tumor progression, metastases, treatment resistance, and
recurrence. Understanding CSC kinetics and interaction with their nonstem counterparts …
recurrence. Understanding CSC kinetics and interaction with their nonstem counterparts …
The tumor invasion paradox in cancer stem cell-driven solid tumors
A Shyntar, A Patel, M Rhodes, H Enderling… - Bulletin of mathematical …, 2022 - Springer
Cancer stem cells (CSCs) are key in understanding tumor growth and tumor progression. A
counterintuitive effect of CSCs is the so-called tumor growth paradox: the effect where a …
counterintuitive effect of CSCs is the so-called tumor growth paradox: the effect where a …
The therapeutic implications of plasticity of the cancer stem cell phenotype
The cancer stem cell hypothesis suggests that tumors contain a small population of cancer
cells that have the ability to undergo symmetric self-renewing cell division. In tumors that …
cells that have the ability to undergo symmetric self-renewing cell division. In tumors that …