Upregulation of Toll‐like receptor 2 (TLR2) plays a critical role in inflammation associated
with ischemia/reperfusion–induced tissue damage. OPN‐305 is the first humanized IgG4 …

Toll‐like receptor‐4 (TLR4) pathways are major contributors to pathological inflammatory
responses induced by tissue damage. NI‐0101 is the first monoclonal antibody (mAb) …

Toll‐like receptors (TLRs) are important molecules involved in the activation of innate and
subsequent development of adaptive immunity. TLRs are ligated by exogenous ligands from …

Toll-like receptor-4 (TLR-4) has been increasingly recognized as playing a critical role in the
pathogenesis of ischemia-reperfusion injury (IRI) of renal grafts. This review provides a …

Background—Reperfusion therapy for myocardial infarction is hampered by detrimental
inflammatory responses partly via Toll-like receptor (TLR) activation. Targeting TLR …

Small nuclear RNA and associated lupus autoantigens activate B cells and dendritic cells
via Toll-like receptor-7 (TLR-7); therefore, TLR-7 may represent a potential therapeutic target …

BACKGROUND: Ischemia-reperfusion injury (I/R) has a negative effect on renal allograft
survival. Using a rat model of kidney IR injury, we demonstrated inhibition of Toll-like …

Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by
Pathogen-and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers …

Ischemia reperfusion (I/R) injury refers to the tissue damage which occurs when blood
supply returns to tissue after a period of ischemia and is associated with trauma, stroke …

Acute kidney injury (AKI) is a common and devastating pathologic condition, associated with
considerable high morbidity and mortality. Although significant breakthroughs have been …