[HTML][HTML] p38 MAPK and PI3K/AKT signalling cascades inParkinson's disease

SK Jha, NK Jha, R Kar, RK Ambasta… - International journal of …, 2015 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …

[HTML][HTML] Role of mitogen activated protein kinase signaling in Parkinson's disease

A Bohush, G Niewiadomska, A Filipek - International journal of molecular …, 2018 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder caused by insufficient dopamine
production due to the loss of 50% to 70% of dopaminergic neurons. A shortage of dopamine …

[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease

A Goyal, A Agrawal, A Verma, N Dubey - Experimental and Molecular …, 2023 - Elsevier
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …

[HTML][HTML] P38 mitogen-activated protein kinase and Parkinson's disease

J He, W Zhong, M Zhang, R Zhang… - Translational …, 2018 - degruyter.com
Parkinson's disease, the second major neurodegenerative disease, has created a great
impact on the elder people. Although the mechanisms underlying Parkinson's disease are …

[HTML][HTML] PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease

N Nakano, S Matsuda, M Ichimura… - International …, 2017 - spandidos-publications.com
Parkinson's disease (PD) is a common progressive and multifactorial neurodegenerative
disease, characterized by the loss of midbrain dopaminergic neurons. Numerous …

Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD

M Iba, C Kim, S Kwon, M Szabo… - Science translational …, 2023 - science.org
Alterations in the p38 mitogen-activated protein kinases (MAPKs) play an important role in
the pathogenesis of dementia with Lewy bodies (DLB) and Parkinson's disease (PD) …

Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease

M Kumar, N Bansal - Molecular neurobiology, 2022 - Springer
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system

K Takeda, H Ichijo - Genes to Cells, 2002 - Wiley Online Library
p38 mitogen‐activated protein kinases (MAPKs), together with extracellular signal‐regulated
kinases (ERKs) and c‐Jun N‐terminal kinases (JNKs), constitute the MAPK family. Multiple …

[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction

C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …

[HTML][HTML] The contribution of microglia to neuroinflammation in Parkinson's disease

K Badanjak, S Fixemer, S Smajić, A Skupin… - International Journal of …, 2021 - mdpi.com
With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …