Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: relevance to oxidative stress and neuroinflammation in Parkinson's …

A Kanthasamy, H Jin, S Mehrotra, R Mishra… - Neurotoxicology, 2010 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative movement disorder
characterized by extensive degeneration of dopaminergic neurons in the nigrostriatal …

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

L Munoz, AJ Ammit - Neuropharmacology, 2010 - Elsevier
Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …

Neuroprotective and therapeutic strategies against Parkinson's disease: recent perspectives

S Sarkar, J Raymick, S Imam - International journal of molecular sciences, 2016 - mdpi.com
Parkinsonism is a progressive motor disease that affects 1.5 million Americans and is the
second most common neurodegenerative disease after Alzheimer's. Typical …

Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis

N Dzamko, J Zhou, Y Huang… - Frontiers in molecular …, 2014 - frontiersin.org
Substantial evidence implicates abnormal protein kinase function in various aspects of
Parkinson's disease (PD) etiology. Elevated phosphorylation of the PD-defining pathological …

Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade

K Maiese, ZZ Chong, S Wang, YC Shang - International journal of …, 2012 - mdpi.com
Oxidative stress impacts multiple systems of the body and can lead to some of the most
devastating consequences in the nervous system especially during aging. Both acute and …

PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …

Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

[HTML][HTML] Damage to dopaminergic neurons by oxidative stress in Parkinson's disease

JD Guo, X Zhao, Y Li, GR Li… - … journal of molecular …, 2018 - spandidos-publications.com
Oxidative stress is increasingly recognized as a central event contributing to the
degeneration of dopaminergic neurons in the pathogenesis of Parkinson's disease (PD) …

Parkinson's disease: a short story of 200 years

L Cuenca, AL Gil Martinez, L Cano Fernandez… - 2019 - digitum.um.es
After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and
incidental neurodegenerative disorder, affecting more than 2% of the population older than …

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease

SAL Corrêa, KL Eales - Journal of signal transduction, 2012 - Wiley Online Library
A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …