The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease

NA Lashgari, NM Roudsari, S Momtaz… - Journal of …, 2021 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and
oxidative stress play key etiopathological role. The pathology of PD brain is characterized by …

Oxidative modification and its implications for the neurodegeneration of Parkinson's disease

J Zhao, S Yu, Y Zheng, H Yang, J Zhang - Molecular neurobiology, 2017 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
major characteristics of PD include the loss of dopaminergic neurons in the substantia nigra …

Inflammatory and cell death pathways in brain and peripheral blood in Parkinson's disease

B Macchi, R Di Paola, F Marino-Merlo… - CNS & neurological …, 2015 - ingentaconnect.com
Evidence has been accumulated showing that inflammatory and cell death pathways are
altered both in brain and periphery during Parkinson disease (PD). Neuronal loss in PD is …

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's …

R Gordon, N Singh, V Lawana, A Ghosh… - Neurobiology of …, 2016 - Elsevier
Chronic microglial activation has been linked to the progressive degeneration of the
nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis …

Oxidative stress and neuroinflammation in the story of Parkinson's disease: could targeting these pathways write a good ending?

K Hassanzadeh, A Rahimmi - Journal of cellular physiology, 2019 - Wiley Online Library
Although, current medications for Parkinson's disease can control and relief symptoms of the
disease efficiently, they are unable to either prevent progression of the disease or maintain …

[HTML][HTML] Functions of p38 MAP kinases in the central nervous system

PR Asih, E Prikas, K Stefanoska, ARP Tan… - Frontiers in molecular …, 2020 - frontiersin.org
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Downregulation of miR-124 in MPTP-treated mouse model of Parkinson's disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 …

N Kanagaraj, H Beiping, ST Dheen, SSW Tay - Neuroscience, 2014 - Elsevier
Parkinson's disease (PD) is a debilitating neurodegenerative disorder causing severe motor
disabilities resulting from the loss of dopaminergic neurons in the substantia nigra pars …

[HTML][HTML] The mechanism and function of glia in Parkinson's disease

X Zhang, R Zhang, MU Nisa Awan… - Frontiers in Cellular …, 2022 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disease that primarily affects elderly
people. The mechanism on onset and progression of PD is unknown. Currently, there are no …

[HTML][HTML] Promising drug targets and associated therapeutic interventions in Parkinson's disease

SN Rai, P Singh, R Varshney… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …