The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease
NA Lashgari, NM Roudsari, S Momtaz… - Journal of …, 2021 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and
oxidative stress play key etiopathological role. The pathology of PD brain is characterized by …
oxidative stress play key etiopathological role. The pathology of PD brain is characterized by …
Oxidative modification and its implications for the neurodegeneration of Parkinson's disease
J Zhao, S Yu, Y Zheng, H Yang, J Zhang - Molecular neurobiology, 2017 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
major characteristics of PD include the loss of dopaminergic neurons in the substantia nigra …
major characteristics of PD include the loss of dopaminergic neurons in the substantia nigra …
Inflammatory and cell death pathways in brain and peripheral blood in Parkinson's disease
B Macchi, R Di Paola, F Marino-Merlo… - CNS & neurological …, 2015 - ingentaconnect.com
Evidence has been accumulated showing that inflammatory and cell death pathways are
altered both in brain and periphery during Parkinson disease (PD). Neuronal loss in PD is …
altered both in brain and periphery during Parkinson disease (PD). Neuronal loss in PD is …
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's …
Chronic microglial activation has been linked to the progressive degeneration of the
nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis …
nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis …
Oxidative stress and neuroinflammation in the story of Parkinson's disease: could targeting these pathways write a good ending?
K Hassanzadeh, A Rahimmi - Journal of cellular physiology, 2019 - Wiley Online Library
Although, current medications for Parkinson's disease can control and relief symptoms of the
disease efficiently, they are unable to either prevent progression of the disease or maintain …
disease efficiently, they are unable to either prevent progression of the disease or maintain …
[HTML][HTML] Functions of p38 MAP kinases in the central nervous system
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …
multitude of mammalian cell types. This review covers recent advances on specific functions …
Parkinson's disease: Mechanisms, translational models and management strategies
C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …
Downregulation of miR-124 in MPTP-treated mouse model of Parkinson's disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 …
Parkinson's disease (PD) is a debilitating neurodegenerative disorder causing severe motor
disabilities resulting from the loss of dopaminergic neurons in the substantia nigra pars …
disabilities resulting from the loss of dopaminergic neurons in the substantia nigra pars …
[HTML][HTML] The mechanism and function of glia in Parkinson's disease
X Zhang, R Zhang, MU Nisa Awan… - Frontiers in Cellular …, 2022 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disease that primarily affects elderly
people. The mechanism on onset and progression of PD is unknown. Currently, there are no …
people. The mechanism on onset and progression of PD is unknown. Currently, there are no …
[HTML][HTML] Promising drug targets and associated therapeutic interventions in Parkinson's disease
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …
availability of symptomatic treatments, response towards the health of PD patients remains …