Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons. Dysregulation of mammalian target of rapamycin (mTOR) has been …

Parkinson disease (PD) used to be considered a nongenetic condition. However, the
identification of several autosomal dominant and recessive mutations linked to monogenic …

Parkinson's disease (PD) is a complex, chronic, and progressive neurodegenerative
disease that is characterized by irreversible dopaminergic neuronal loss in the substantia …

Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …

Current therapies for Parkinson's disease significantly improve the quality of life for patients
suffering from this neurodegenerative disease, yet none of the current therapies has been …

Parkinson's disease (PD) is a movement disorder caused by degeneration of the
nigrostriatal dopamine (DA) neurons in the substantia nigra pars compacta and the resultant …

Parkinson's disease (PD) is caused by progressive neurodegeneration of dopaminergic
(DAergic) neurons with abnormal accumulation of α-synuclein in substantia nigra (SN) …

The combination of genetics and genomics in Parkinson´ s disease has recently begun to
unveil molecular mechanisms possibly underlying disease onset and progression. In …

Alzheimer's disease is a progressive neurodegenerative disease characterized by the
presence of amyloid-β plaques in the extracellular environment and aggregates of Tau …

Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …