Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of …
Y Xu, C Liu, S Chen, Y Ye, M Guo, Q Ren, L Liu… - Cellular signalling, 2014 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons. Dysregulation of mammalian target of rapamycin (mTOR) has been …
dopaminergic neurons. Dysregulation of mammalian target of rapamycin (mTOR) has been …
Parkinson disease: translating insights from molecular mechanisms to neuroprotection
SK Pirooznia, LS Rosenthal, VL Dawson… - Pharmacological …, 2021 - ASPET
Parkinson disease (PD) used to be considered a nongenetic condition. However, the
identification of several autosomal dominant and recessive mutations linked to monogenic …
identification of several autosomal dominant and recessive mutations linked to monogenic …
[HTML][HTML] Neuroinflammation in parkinson's disease and its treatment opportunities
Parkinson's disease (PD) is a complex, chronic, and progressive neurodegenerative
disease that is characterized by irreversible dopaminergic neuronal loss in the substantia …
disease that is characterized by irreversible dopaminergic neuronal loss in the substantia …
The role of PI3K/Akt and ERK in neurodegenerative disorders
SN Rai, H Dilnashin, H Birla, SS Singh, W Zahra… - Neurotoxicity …, 2019 - Springer
Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
[HTML][HTML] Targets for neuroprotection in Parkinson's disease
TA Yacoubian, DG Standaert - … et biophysica acta (BBA)-Molecular basis of …, 2009 - Elsevier
Current therapies for Parkinson's disease significantly improve the quality of life for patients
suffering from this neurodegenerative disease, yet none of the current therapies has been …
suffering from this neurodegenerative disease, yet none of the current therapies has been …
Inflammatory process in Parkinson's disease: role for cytokines
Parkinson's disease (PD) is a movement disorder caused by degeneration of the
nigrostriatal dopamine (DA) neurons in the substantia nigra pars compacta and the resultant …
nigrostriatal dopamine (DA) neurons in the substantia nigra pars compacta and the resultant …
The role of oxidative stress in Parkinson's disease
KH Chang, CM Chen - Antioxidants, 2020 - mdpi.com
Parkinson's disease (PD) is caused by progressive neurodegeneration of dopaminergic
(DAergic) neurons with abnormal accumulation of α-synuclein in substantia nigra (SN) …
(DAergic) neurons with abnormal accumulation of α-synuclein in substantia nigra (SN) …
A new hypothesis for Parkinson's disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics
J Obergasteiger, G Frapporti, PP Pramstaller… - Molecular …, 2018 - Springer
The combination of genetics and genomics in Parkinson´ s disease has recently begun to
unveil molecular mechanisms possibly underlying disease onset and progression. In …
unveil molecular mechanisms possibly underlying disease onset and progression. In …
G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer's disease
SE Desale, H Chidambaram, S Chinnathambi - Molecular Biomedicine, 2021 - Springer
Alzheimer's disease is a progressive neurodegenerative disease characterized by the
presence of amyloid-β plaques in the extracellular environment and aggregates of Tau …
presence of amyloid-β plaques in the extracellular environment and aggregates of Tau …
Biomarker of neuroinflammation in Parkinson's disease
TW Liu, CM Chen, KH Chang - International journal of molecular sciences, 2022 - mdpi.com
Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …