It has been demonstrated in invertebrate species that the evolutionarily conserved insulin
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …

Although the underlying mechanisms of longevity are not fully understood, it is known that
mutation in genes that share similarities with those in humans involved in the insulin/insulin …

Hormones, like insulin and insulin-like growth factor 1 (IGF-1), are thought to be deeply
involved with longevity. Lower species have been the source for most of our current …

Ageing may be controlled by a genetic-hormonal system that may have originated from a
very early common ancestor. One of the pathways that has been implicated in ageing is the …

In invertebrates, signaling pathways homologous to mammalian insulin and insulin-like
growth factor (IGF-1) signal transduction have a major role in the control of longevity. There …

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in
species throughout the animal kingdom. This life-extension pathway, the first to be defined …

Insulin/insulin-like growth factor (IGF) signaling plays a major role in thecontrol of aging and
life span ininvertebrates. Major extension of life span ingrowth hormone receptor knock out …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

Evidence is accumulating that aging is hormonally regulated by an evolutionarily conserved
insulin/IGF‐1 signalling (IIS) pathway. Mutations in IIS components affect lifespan in …

Human aging is currently defined as a physiological decline of biological functions in the
body with a continual adaptation to internal and external damaging. The endocrine system …