Thymoquinone potentiates methotrexate mediated-apoptosis in Saos-2 osteosarcoma cell line

A Valizadeh, D Shanehbandi, B Yousefi… - Drug …, 2022 - thieme-connect.com
Introduction Recently, various studies have concentrated on the therapeutic potential of
thymoquinone (TQ), a natural polyphenol, in various human malignancies, including …

Antiproliferative effect of thymoquinone on human colon cancer cells: Is it dependent on glycolytic pathway?

M Özkoç, EM Altundag - Acıbadem Üniversitesi Sağlık …, 2023 - journal.acibadem.edu.tr
Purpose: In the present study, we aimed to investigate the anti-proliferative effect and
metabolic activity of thymoquinone (TQ) on colon cancer cells (HCT-116). Material and …

Thymoquinone, as a novel therapeutic candidate of cancers

B Almajali, HAN Al-Jamal, WRW Taib, I Ismail… - Pharmaceuticals, 2021 - mdpi.com
To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for …

Inhibition of proliferation and induction of apoptosis by thymoquinone via modulation of TGF family, p53, p21 and Bcl-2α in leukemic cells

M Diab-Assaf, J Semaan, M El-Sabban… - Anti-Cancer Agents …, 2018 - ingentaconnect.com
Introduction: Adult T-cell leukemia (ATL) is an aggressive form of malignancy caused by
human T-cell lymphotropic virus 1 (HTLV-1). Currently, there is no effective treatment for …

[PDF][PDF] Thymoquinone's Potential Role in Cancer Chemotherapy: A Mini Review

NMA Mahmood, KS Hamaamin - Al-Rafidain Journal of Medical Sciences …, 2022 - iasj.net
Background: Pollution and genetic factors have increased the likelihood of cancer in the
developing world. Cancer is now the leading cause of death in young patients. Scientists are …

[HTML][HTML] Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

YK Mahmoud, HMA Abdelrazek - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Recently, there is growing interest in the natural bioactive components having anticancer
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …

Quercetin derivatives as potential therapeutic agents: an updated perspective on the treatment of nicotine-induced non-small cell lung cancer

NA Alsharairi - International Journal of Molecular Sciences, 2023 - mdpi.com
Flavonoids are the largest group of polyphenols, represented by many compounds that
exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin …

Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway

CC Woo, SY Loo, V Gee, CW Yap, G Sethi… - Biochemical …, 2011 - Elsevier
Thymoquinone (TQ), an active ingredient of Nigella sativa, has been reported to exhibit anti-
oxidant, anti-inflammatory and anti-tumor activities through mechanism (s) that is not fully …

[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …

Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells

G Adinew, SS Messeha, R Badisa, E Taka… - The FASEB …, 2022 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a
metastatic nature. TNBC lacks the expression of the progesterone receptor, estrogen …