Living bacteria therapies have been proposed as an alternative approach to treating a broad
array of cancers. In this study, we developed a genetically encoded microbial encapsulation …

With increasing evidence that microbes colonize tumors, synthetic biology tools are being
leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered …

The human body is a natural habitat for a multitude of microorganisms, with bacteria being
the major constituent of the microbiota. These bacteria colonize discrete anatomical …

The complex gastrointestinal environment and the intestinal epithelial barrier constrain the
design and effectiveness of orally administered tumour vaccines. Here we show that outer …

Microbial therapy has shown remarkable clinical success. However, insufficient colonization
of transplanted microbes at the location of interest and the complexity of mechanisms and …

Synthetic biology is driving a new era of medicine through the genetic programming of living
cells,. This transformative approach allows for the creation of engineered systems that …

Anti-cancer therapy faces major challenges, particularly in terms of specificity of treatment.
The ideal therapy would eradicate tumour cells selectively with minimum side effects on …

Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

A number of recent reports have demonstrated that attenuated Salmonella typhimurium are
capable of targeting both primary and metastatic tumors. The use of bacteria as a vehicle for …

Increasing evidence implicates the tumor microbiota as a factor that can influence cancer
progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics …