Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

The vast majority of proteins that a cell secretes or displays on its surface first enter the
endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled …

In all eukaryotic cells, the endoplasmic reticulum (ER) is an intracellular organelle where
folding and assembly occurs for proteins destined to the extracellular space, plasma …

The endoplasmic reticulum (ER) is the principal cellular organelle in which correct folding
and maturation of transmembrane, secretory, and ER-resident proteins occur. Research …

The extensive membrane network of the endoplasmic reticulum (ER) is physically
juxtaposed to and functionally entwined with essentially all other cellular compartments …

The unfolded protein response (UPR) is an intracellular signaling pathway that is activated
by the accumulation of unfolded proteins in the endoplasmic reticulum (ER). UPR activation …

Increased demands on the protein folding capacity of the endoplasmic reticulum (ER) trigger
the unfolded protein response (UPR). Comprised of a tripartite signaling system, the UPR …

Proteins requiring post‐translational modifications such as N‐linked glycosylation are
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …

Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized
secretory cells and is also involved in the pathogenesis of many human diseases. ER stress …