Parkinson's disease is characterized by accumulation of α-synuclein (αSyn). Release of
oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via …

Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder and is characterized by the formation of cellular inclusions inside neurons that are …

Synucleinopathies such as Parkinson's disease (PD) are hallmarked by α‐synuclein (α‐syn)
pathology and neuroinflammation. This neuroinflammation involves activated microglia with …

Parkinson's disease (PD) is characterized by a profound loss of dopaminergic neurons in
the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction …

Abstract Background α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease
(PD), has been recognized to induce the production of interleukin-1β in a process that …

Persistent microglia-mediated neuroinflammation is a major pathophysiological contributor
to the progression of Parkinson's disease (PD), but the cell-signaling mechanisms governing …

Parkinson's disease (PD) is an age-related movement disorder characterized by a
progressive degeneration of dopaminergic neurons in the midbrain. Although the presence …

Background Parkinson's disease (PD) is characterized by the loss of nigral dopaminergic
neurons leading to impaired striatal dopamine signaling, α-synuclein-(α-syn-) rich …

Alpha-synuclein (αSynAgg) are pathological hallmarks of Parkinson's disease (PD) and
other synucleinopathies that induce microglial activation and immune-mediated …

Recent findings in human samples and animal models support the involvement of
inflammation in the development of Parkinson's disease. Nevertheless, it is currently …