Nitric oxide–independent relaxations to acetylcholine and A23187 involve different routes of heterocellular communication: role of gap junctions and phospholipase …
IR Hutcheson, AT Chaytor, WH Evans… - Circulation …, 1999 - Am Heart Assoc
NO-and prostanoid-independent relaxations are generally assumed to be mediated by an
endothelium-derived hyperpolarizing factor (EDHF) that has been postulated to be an …
endothelium-derived hyperpolarizing factor (EDHF) that has been postulated to be an …
Central role of heterocellular gap junctional communication in endothelium‐dependent relaxations of rabbit arteries
AT Chaytor, WH Evans, TM Griffith - The Journal of physiology, 1998 - Wiley Online Library
1 The contribution of gap junctions to endothelium‐dependent relaxation was investigated in
isolated rabbit conduit artery preparations pre‐constricted by 10 μM phenylephrine (PhE). 2 …
isolated rabbit conduit artery preparations pre‐constricted by 10 μM phenylephrine (PhE). 2 …
Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H2O2 in NO-independent relaxations of rabbit arteries
AT Chaytor, DH Edwards… - Proceedings of the …, 2003 - National Acad Sciences
We have compared the contributions of gap junctional communication and chemical
signaling via H2O2 to NO-independent relaxations evoked by the Ca2+ ionophore A23187 …
signaling via H2O2 to NO-independent relaxations evoked by the Ca2+ ionophore A23187 …
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation
H Shimokawa, H Yasutake, K Fujii… - Journal of …, 1996 - journals.lww.com
Endothelium-dependent relaxations are achieved by a combination of endothelium-derived
prostacyclin (PGI 2), nitric oxide (NO), and endothelium-derived hyperpolarizing factor …
prostacyclin (PGI 2), nitric oxide (NO), and endothelium-derived hyperpolarizing factor …
Inhibition of endothelium-dependent vascular relaxation by lysophosphatidylcholine: impact of lysophosphatidylcholine on mechanisms involving endothelium …
DE Froese, J McMaster, RYK Man, PC Choy… - Molecular and cellular …, 1999 - Springer
Hyperlipidemia has been associated with an increase in the incidence of atherosclerosis.
The oxidation of low density lipoprotein (LDL) plays an important role in the initiation and …
The oxidation of low density lipoprotein (LDL) plays an important role in the initiation and …
The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization
TM Griffith, AT Chaytor, DH Edwards - Pharmacological research, 2004 - Elsevier
Although an endothelium-derived hyperpolarizing factor (EDHF) has often been
hypothesized to underpin vascular relaxations that are independent of nitric oxide (NO) and …
hypothesized to underpin vascular relaxations that are independent of nitric oxide (NO) and …
cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions
TM Griffith, AT Chaytor, HJ Taylor… - Proceedings of the …, 2002 - National Acad Sciences
We have investigated the role of cAMP in NO-and prostanoid-independent relaxations that
are widely attributed to an endothelium-derived hyperpolarizing factor (EDHF). Under …
are widely attributed to an endothelium-derived hyperpolarizing factor (EDHF). Under …
Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries
HJ Taylor, AT Chaytor, DH Edwards… - … and biophysical research …, 2001 - Elsevier
We have investigated the role of cAMP in nitric oxide (NO)-and prostanoid-independent
vascular relaxations evoked by acetylcholine (ACh) in isolated arteries and perfused ear …
vascular relaxations evoked by acetylcholine (ACh) in isolated arteries and perfused ear …
Role of gap junctions in acetylcholine-induced vasodilation of proximal and distal arteries of the rat mesentery
CE Hill, H Hickey, SL Sandow - Journal of the autonomic nervous system, 2000 - Elsevier
We have previously shown that myoendothelial gap junctions are more prevalent in distal
than in proximal arteries of the rat mesentery. In the present study we have investigated the …
than in proximal arteries of the rat mesentery. In the present study we have investigated the …
Role of heterocellular Gap junctional communication in endothelium-dependent smooth muscle hyperpolarization: inhibition by a connexin-mimetic peptide
A synthetic connexin-mimetic peptide (Gap 27 peptide) was used to evaluate the
contribution of gap junctional communication to smooth muscle responses mediated by the …
contribution of gap junctional communication to smooth muscle responses mediated by the …
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