The discovery of alpha-synuclein's prion-like behaviors in mammals, as well as a non-
Mendelian type of inheritance, has led to a new concept in biology, the “prion hypothesis” of …

Formation and aggregation of misfolded proteins in the central nervous system (CNS) is a
key hallmark of several age-related neurodegenerative diseases, including Parkinson's …

Pathologic intracellular inclusions formed from polymers of misfolded α-synuclein (αsyn)
protein define a group of neurodegenerative diseases termed synucleinopathies which …

The principal pathogenic event in Parkinson's disease is characterized by the
conformational change of α-synuclein, which form pathological aggregates of misfolded …

Parkinson's disease is one of several neurodegenerative diseases associated with a
misfolded, aggregated and pathological protein. In Parkinson's disease this protein is alpha …

Parkinson's disease (PD) and multiple system atrophy (MSA) are distinct clinical syndromes
characterized by the pathological accumulation of α-synuclein (α-syn) protein fibrils in …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Abstract Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system
atrophy (MSA) are neurodegenerative disorders which have been pathologically classified …

For more than a decade, the “prion-like” hypothesis for Parkinson's disease (PD) has
remained one of the most controversial topics in neurodegenerative disease research [21 …