Background Multiple sclerosis (MS), one of the most common diseases of the central
nervous system (CNS), is characterized by demyelination and chronic inflammation of the …

CD39, an ectonucleotidase that hydrolyses pro-inflammatory ATP, is a marker of highly
active and suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg …

OBJECTIVE: CD4+CD25+ regulatory T cells (Tregs) have been found to have a decreased
effector function in patients with multiple sclerosis (MS). In this study, we co-cultured naïve …

Multiple sclerosis (MS) is an autoimmune disease characterized by defect in regulatory
function of CD4+ CD25+ T cells. We demonstrated difference in proportion of regulatory T …

Multiple sclerosis (MS) is a neuro-immunological demyelinating disease. From the
immunological aspects, it is well accepted that T cells play a pivotal role in the etiology of the …

Summary Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in
controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an …

Patients with relapsing-remitting multiple sclerosis (RR-MS) show a suboptimal CD4+
CD25+ regulatory T cell (Treg) function, whereas no Treg alterations are observed in …

Background Accumulating evidence indicates that regulatory T cells (Tregs) play an
important role in the maintenance of immune tolerance. And dysfunction or deficiency of …

Accumulating evidence indicates an immunosuppressive role for CD4+ CD25+ regulatory T
cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with …

Resting and activated subpopulations of CD4+ CD25+ CD127loT regulatory cells (Treg) and
CD4+ CD25+ CD127+ effector T cells in MS patients and in healthy individuals were …