Major depressive disorder (MDD) is a common and severe disease characterized by mood
changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the …

Major depression is a highly prevalent severe mood disorder that is treated with
antidepressants. The molecular targets of antidepressants require definition. We …

Major depressive disorder (MDD) is a complicated multifactorial induced disease,
characterized by depressed mood, anhedonia, fatigue, and altered cognitive function …

Although multiple hypotheses had been proposed to clarify the causes of depression, the
accurate pathogenesis and effective treatment of depression still need to be solved …

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of
disorders, in particular major depression and neuropathic pain. In the 1970s the ability of …

Correlational and causal comparative research link ceramide (Cer), the precursor of
complex sphingolipids, to some psychiatric (eg, depression, schizophrenia (SZ), alcohol use …

Background Major depressive disorder is a significant contributor to global disability and
mortality. The mechanisms of depression are vast and not fully understood, and as a result …

Autophagy has been recognized as evolutionary conserved intracellular pathway that
ensures energy, organelle, and protein homeostasis through lysosomal degradation of …

Major depression is a systems disorder which impairs not only central nervous system
aspects of mood and behavior but also peripheral organ systems. Current views on the …

In the search for antidepressants'(ADs') mechanisms of action beyond their influence on
monoaminergic neurotransmission, we analyzed the effects of three structurally and …