Triplex-forming oligonucleotides (TFOs) are among the most specific DNA ligands and
represent an important tool for specific regulation of gene expression. TFOs have also been …

Human topoisomerase II (topo II) is the cellular target for a number of widely used antitumor
agents, such as etoposide (VP16). These agents 'poison'the enzyme and induce it to …

Topoisomerase I is a ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins (CPTs). These drugs stimulate DNA cleavage by …

To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming …

Abstract Amsacrine-4-carboxamide-oligonucleotide conjugates were synthesized and
studied for their capacity to form DNA triple helices and to alter human topoisomerase II …

In this article, 13 short chains that can form G-quadruplex and quadruplex-duplex motif have
been designed. Fourteen oligonucleotides, including 13 short chains as well as a reference …

Triple helix‐forming oligonucleotides covalently linked to topoisomerase I inhibitors, in
particular the antitumor agent camptothecin, trigger topoisomerase I‐mediated DNA …

There is considerable interest in the development of sequence-selective DNA drugs.
Chemical agents able to interfere with DNA topoisomerases-essential nuclear enzymes-are …

The sequence-specific targeting of duplex DNA using triple helix-forming oligonucleotides
(TFOs) has attracted broad attention. 1 Currently, all such attempts to target DNA have used …

Topoisomerase I (topo I) is a ubiquitous DNA-cleaving enzyme and an important therapeutic
target in cancer chemotherapy. Camptothecins (CPTs) reversibly trap topo I in covalent …