The activation of the nuclear receptor peroxisome proliferator-activated receptor-γ (PPAR-γ)
is known to exert anti-inflammatory and neuroprotective effects and PPAR-γ agonists are …

We have previously shown that natural (15-deoxy-Δ12, 14-prostaglandin J2) and synthetic
(pioglitazone) agonists of peroxisome proliferator-activated receptor γ (PPAR-γ) strengthen …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is one of the most studied nuclear
receptor since its identification as a target to treat metabolic and neurological diseases. In …

Several lines of evidence suggest that peroxisome proliferator-activated receptor-γ (PPAR-γ)
agonists may control brain inflammation and, therefore, may be useful for the treatment of …

Peroxisome proliferator-activated receptor gamma (PPARγ) belongs to a family of ligand-
activated transcription factors, and its ligands are known to control many physiological and …

Mitochondrial defects, affecting parameters such as mitochondrial number and shape, levels
of respiratory chain complex components and markers of oxidative stress, have been …

TNFα has been implicated in several demyelinating disorders, including multiple sclerosis
(MS) and X‐adrenoleukodystrophy (X‐ALD). TNFα abundance is greatly increased in the …

An adequate protection from oxidative and inflammatory reactions, together with the
promotion of oligodendrocyte progenitor (OP) differentiation, is needed to recover from …

Background Inflammation is known to play a pivotal role in mediating neuronal damage and
axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory …

Neuronal cell impairment, such as that induced by amyloid-beta (Aβ) protein, is a process
with limited therapeutic interventions and often leads to long-term neurodegeneration …