Stathmin-1 (STMN1) is a microtubule-destabilizing protein which is overexpressed in
cancer. Its overexpression is associated with poor prognosis and also serves as a predictive …

Stathmin1 (STMN1) is a microtubule modulator that is expressed in multiple cancers and
correlates with poor survival. We previously demonstrated in vivo safety of bifunctional (bi) …

Bifunctional small hairpin RNAs (bi-shRNAs) are functional miRNA/siRNA composites that
are optimized for posttranscriptional gene silencing through concurrent mRNA cleavage …

Stathmin (STMN) plays a vital role in maintaining the malignant behavior of cancer through
directly regulating microtubule dynamics equilibrium. Taxol, an effective chemotherapeutics …

Abstract Background and Aim We have reported previously that RNA interference targeting
stathmin1 (STMN1) gene in human gastric cancer cells inhibits proliferation in vitro and …

RNA interference (RNAi) is a natural cellular regulatory process that inhibits gene
expression by transcriptional, post-transcriptional and translational mechanisms. Synthetic …

Background Gastric cancer is highly aggressive disease. Despite advances in diagnosis
and therapy, the prognosis is still poor. Various genetic and molecular alterations are found …

Metastatic neuroblastoma is an aggressive childhood cancer of neural crest origin. Stathmin,
a microtubule destabilizing protein, is highly expressed in neuroblastoma although its …

Gene silencing agents such as small interfering RNA (siRNA) and microRNA offer the
promise to modulate expression of almost every gene for the treatment of human diseases …

STAT3 plays a particularly important role in several cancer-related signal transduction
pathways. Silencing STAT3 via RNA interference or small molecule inhibitors induces the …