Study Objectives Rapid eye movement (REM) sleep behavior disorder (RBD) is a
parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely …

Background Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the
earliest and most specific prodromes of the α-synucleinopathies including Parkinson's …

Study Objectives: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a
harbinger of synuclein-mediated neurodegenerative diseases. It is unknown if this also …

Objectives Hyperechogenicity of the substantia nigra (SN) and abnormal dopamine
transporter-single-photon emission computed tomography (DAT-SPECT) are biomarkers …

Background Idiopathic REM sleep behaviour disorder (iRBD) has been recognised as a
significant biomarker for developing a neurodegenerative alpha-synucleinopathy, which is …

Objective: Explore non-REM Sleep with Hypertonia (NRSH) as a biomarker in alpha-
synuclein related diseases. Background: REM sleep without atonia (RSWA) is the principal …

Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD),
characterized by rapid eye movement sleep without atonia (RSWA) and dream-enactment …

Sleep disturbances are common problems in patients with Parkinson's disease (PD) caused
by various factors including nocturnal motor symptoms, psychiatric symptoms, dementia …

Background The clinical characteristics of Parkinson's disease (PD) differ between men and
women, and late-and early-onset patients, including motor symptoms and some nonmotor …

Introduction The earliest stages of alpha-synucleinopathies are accompanied by non-
specific prodromal symptoms such as diminished sense of smell, constipation and …