Cardiac remodeling involves molecular, cellular, and in-terstitial changes that manifest
clinically as changes in size, shape, and function of the heart after injury or stress …

The mammalian heart during its development and in response to physiological or
pathological stimuli undergoes hypertrophic enlargement, a consequence of an increase in …

Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

In the past decades, the cardiovascular community has laid out the fundamental signaling
cascades that become awry in the cardiomyocyte during the process of pathologic cardiac …

▪ Abstract This review discusses the rapidly progressing field of cardiomyocyte signal
transduction and the regulation of the hypertrophic response. When stimulated by a wide …

Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Cardiac hypertrophy is an adaptive response of the heart to a variety of intrinsic and extrinsic
stimuli. The hypertrophic response, during which cardiomyocytes increase in size without …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

The mammalian heart is a dynamic organ that can grow and change to accommodate
alterations in its workload. During development and in response to physiological stimuli or …