A remarkable aspect of the interaction of Cryptococcus neoformans with mammalian hosts is
a consistent increase in capsule volume. Given that many aspects of the interaction of C …

Cryptococcus neoformans and distantly related fungal species release extracellular vesicles
that traverse the cell wall and contain a varied assortment of components, some of which …

Cryptococcus neoformans (Cn) is a soil fungus that causes life-threatening meningitis in
immunocompromised patients and is a facultative intracellular pathogen capable of …

Despite a presumed critical role of macrophages in the host response to cryptococcal
infections, previous studies have failed to show growth inhibition of encapsulated …

Phagosomal acidification is a critical cellular mechanism for the inhibition and killing of
ingested microbes by phagocytic cells. The acidic environment activates microbicidal …

Background The interaction between macrophages and Cryptococcus neoformans (Cn) is
critical for containing dissemination of this pathogenic yeast. However, Cn can either lyse …

Capsule production is common among bacterial species, but relatively rare in eukaryotic
microorganisms. Members of the fungal Cryptococcus genus are known to produce …

Cryptococcus neoformans, an encapsulated fungal pathogen, causes meningoencephalitis
in immunocompromised patients. Recent in vivo studies have demonstrated that C …

Recently, we demonstrated that human monocyte-derived macrophages (MDM) treated with
chloroquine or ammonium chloride had markedly increased antifungal activity against the …

Escape from the intravascular compartment is likely a critical step in the development of
hematogenously disseminated cryptococcal infections, such as meningitis. The capsule of …