Intercellular communication within the bone marrow niche significantly promotes
leukemogenesis and provides protection of leukemic cells from therapy. Secreted factors …

Acute lymphoblastic leukemia (ALL) cells disrupt the healthy bone marrow
microenvironment to create a leukemic niche that is crucial for facilitating leukemogenesis …

Acute lymphoblastic leukemia (ALL) cells reside in the bone marrow microenvironment
which nurtures and protects cells from chemotherapeutic drugs. The disruption of cell-cell …

Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular
communication in the leukemic bone marrow participates in disease development …

Highlights•Hematopoietic progenitors are interconnected by F-actin-dependent TNTs.•Cell
dislodgement is the primary mechanism responsible for TNT biogenesis.•TNTs emerge from …

Our vision of cancer has changed during the past decades. Indeed tumors are now
perceived as complex entities where tumoral and stromal components interact closely …

The interaction between acute myeloid leukemia cells (AML) with the bone marrow stroma
cells (BMSCs) determines a protective environment that favors tumor development and …

Chronic myeloid leukemia (CML) is a malignant disorder of hematopoietic stem/progenitor
cells. Majority of patients can be effectively treated with tyrosine kinase inhibitors (TKIs) such …

Tunneling nanotubes (TNTs) are thin membrane tubes connecting remote cells and allowing
the transfer of cellular content. TNTs have been reported in several cancer in vitro, ex vivo …

Tunneling nanotubes (TNTs) are intercellular conduits, which meet the communication
needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred …