[HTML][HTML] A-to-I RNA editing does not change with age in the healthy male rat brain

AP Holmes, SH Wood, BJ Merry, JP de Magalhaes - Biogerontology, 2013 - Springer
RNA editing is a post-transcriptional process, which results in base substitution
modifications to RNA. It is an important process in generating protein diversity through …

Age-related gene-specific changes of A-to-I mRNA editing in the human brain

A Nicholas, JP De Magalhaes, Y Kraytsberg… - Mechanisms of ageing …, 2010 - Elsevier
A-to-I editing is an adenosine-to-inosine modification of mRNA particularly widespread in
the human brain, where it affects thousands of genes. A growing body of evidence suggests …

Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains

Z Li, H Bammann, M Li, H Liang, Z Yan, YPP Chen… - Rna, 2013 - rnajournal.cshlp.org
Adenosine-to-inosine (A-to-I) substitutions are the most common type of RNA editing in
mammals. A-to-I RNA editing is particularly widespread in the brain and is known to play …

[HTML][HTML] Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue

Y Ma, EB Dammer, D Felsky, DM Duong… - Nature …, 2021 - nature.com
RNA editing is a feature of RNA maturation resulting in the formation of transcripts whose
sequence differs from the genome template. Brain RNA editing may be altered in …

[HTML][HTML] Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing

RT O'Neil, X Wang, MV Morabito, RB Emeson - Molecular brain, 2017 - Springer
Abstract A-to-I RNA editing is an important process for generating molecular diversity in the
brain through modification of transcripts encoding several proteins important for neuronal …

Using mouse models to unlock the secrets of non-synonymous RNA editing

H Jinnah, RJ Ulbricht - Methods, 2019 - Elsevier
The deamination of adenosine to inosine by RNA editing is a widespread post-
transcriptional process that expands genetic diversity. Selective substitution of inosine for …

RNA editing level in the mouse is determined by the genomic repeat repertoire

Y Neeman, EY Levanon, MF Jantsch, E Eisenberg - Rna, 2006 - rnajournal.cshlp.org
A-to-I RNA editing is the conversion of adenosine to inosine in double-stranded cellular and
viral RNAs. Recently, abundant editing of human transcripts affecting thousands of genes …

[HTML][HTML] RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

P Sebastiani, M Montano, A Puca, N Solovieff… - PloS one, 2009 - journals.plos.org
Background The strong familiality of living to extreme ages suggests that human longevity is
genetically regulated. The majority of genes found thus far to be associated with longevity …

[HTML][HTML] Abnormalities in A-to-I RNA editing patterns in CNS injuries correlate with dynamic changes in cell type composition

N Gal-Mark, L Shallev, S Sweetat, M Barak, J Billy Li… - Scientific reports, 2017 - nature.com
Adenosine to Inosine (A-to-I) RNA editing is a co-or post-transcriptional mechanism that
modifies genomically encoded nucleotides at the RNA level. A-to-I RNA editing is abundant …

Is abundant A-to-I RNA editing primate-specific?

E Eisenberg, S Nemzer, Y Kinar, R Sorek, G Rechavi… - Trends in Genetics, 2005 - cell.com
A-to-I RNA editing is common in all eukaryotes, and is associated with various neurological
functions. Recently, A-to-I editing was found to occur frequently in the human transcriptome …