The propagation of force in epithelial tissues requires that the contractile cytoskeletal
machinery be stably connected between cells through E-cadherin-containing adherens …

Cells integrate biochemical and mechanical information to function within multicellular
tissue. Within developing and remodeling tissues, mechanical forces contain instructive …

In this chapter, we discuss the cell biology of contractility at cell–cell junctions. As discussed
elsewhere in this volume, contractile forces play key roles in development and tissue …

In epithelial tissues, cells constantly generate and transmit forces between each other.
Forces generated by the actomyosin cytoskeleton regulate tissue shape and structure and …

Adhesions are a central mechanism by which cells mechanically interact with the
surrounding extracellular matrix (ECM) and neighboring cells. In both cell–ECM and cell …

Mechanical stress is increasingly being shown to be a potent modulator of cell–cell
junctional morphologies in developmental and homeostatic processes. Intercellular force …

Actomyosin II contractility in epithelial cell plays an essential role in tension-dependent
adhesion strengthening. One key unsettling question is how cellular contraction transmits …

Simple Summary All cells in the human body experience force. To withstand these forces,
cells rearrange and reinforce their cytoskeletons. In this review, we describe the structure of …

Actomyosin contractility affects cellular organization within tissues in part through the
generation of mechanical forces at sites of cell–matrix and cell–cell contact. While increased …

During epithelial contraction, cells generate forces to constrict their surface and,
concurrently, fine-tune the length of their adherens junctions to ensure force transmission …