Sickle cell hemoglobin (HbS) polymerization is considered to be the primary pathogenic
event in the sickle cell anemia. Many cellular and molecular factors have been identified so …

For insights into the mechanisms of heme action on the rate of sickle cell hemoglobin
polymerization, we determine the erythrocytic concentration of free heme using a novel …

In search of novel control parameters for the polymerization of sickle cell hemoglobin (HbS),
the primary pathogenic event of sickle cell anemia, we explore the role of free heme, which …

The polymerization of sickle cell hemoglobin (HbS) in the erythrocytes of sickle cell anemia
patients is the primary event in the pathophysiology of this debilitating and deadly disease …

Sickle cell anaemia is associated with a mutant haemoglobin, HbS, which forms polymers in
the red blood cells of patients. The primary role of the HbS polymerization for the …

Sickle cell hemoglobin (HbS) is an example of a genetic variant of human hemoglobin
where a point mutation in the β globin gene results in substitution of glutamic acid to valine …

I would like to express my deep and sincere gratitude to my advisor, Professor Frank
Ferrone. His immense knowledge and wide view in the field of biophysics have been great …

Recent work has enabled us to quantitate the four variables (2, 3-DPG concentration, pHi,
non-S hemoglobin composition, and O2 saturation) that modulate the equilibrium solubility …

Abstract 70 years ago, Linus Pauling, the legendary genius of 20th century chemistry,
published his famous work on the molecular cause of sickle cell disease, a paper that gave …

In the last few years, the understanding of the molecular basis of sickle cell disease has
progressed rapidly. It is now possible to describe the structure of the gel of polymerized …