Dose-dependent effects of phytoestrogens on bone

ZC Dang, C Lowik - Trends in Endocrinology & Metabolism, 2005 - cell.com
Phytoestrogens have the potential to maintain bone health and delay or prevent
osteoporosis. This review focuses on their dose-dependent effects on bone and their …

A mini review on osteoporosis: from biology to pharmacological management of bone loss

KY Chin, BN Ng, MKI Rostam… - Journal of Clinical …, 2022 - mdpi.com
Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass
and microarchitecture, which compromises bone strength. It is a complex multifactorial …

Effects of isoflavone interventions on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

K Sansai, M Na Takuathung, R Khatsri… - Osteoporosis …, 2020 - Springer
Isoflavones have a structure similar to 17β-estradiol, so they may be useful to
postmenopausal women in preventing bone loss related to estrogen deficiency. The present …

Genetic and acquired factors influencing the effectiveness and toxicity of drug therapy in osteoporosis

L López-Delgado, L Riancho-Zarrabeitia… - Expert opinion on drug …, 2016 - Taylor & Francis
Introduction: Osteoporosis is a highly prevalent skeletal disorder characterized by
compromised bone strength, usually related to decreased bone mass and microstructural …

Therapeutic approach of natural products that treat osteoporosis by targeting epigenetic modulation

G Zhang, Z Liu, Z Li, B Zhang, P Yao, Y Qiao - Frontiers in Genetics, 2023 - frontiersin.org
Osteoporosis (OP) is a metabolic disease that affects bone, resulting in a progressive
decrease in bone mass, quality, and micro-architectural degeneration. Natural products …

The quest for osteoporosis mechanisms and rational therapies: how far we've come, how much further we need to go

SC Manolagas - Journal of Bone and Mineral Research, 2018 - academic.oup.com
During the last 40 years, understanding of bone biology and the pathogenesis of
osteoporosis, the most common and impactful bone disease of old age, has improved …

Osteoporosis: the role of genetics and the environment

B Ongphiphadhanakul - Nutrigenomics-Opportunities in Asia, 2007 - karger.com
Osteoporosis is partly genetically determined. The genetics of osteoporosis is polygenic in
nature with multiple common polymorphic alleles interacting with each other and …

Isoflavone and bone metabolism: Its cellular mechanism and preventive role in bone loss

M Yamaguchi - Journal of health science, 2002 - jstage.jst.go.jp
Bone loss with increasing age induces osteoporosis. This loss may be due to increased
bone resorption and decreased bone formation. Osteoporosis with a decrease in bone mass …

Osteoporosis: modern paradigms for last century's bones

MC Kruger, FM Wolber - Nutrients, 2016 - mdpi.com
The skeleton is a metabolically active organ undergoing continuously remodelling. With
ageing and menopause the balance shifts to increased resorption, leading to a reduction in …

Osteoporosis: molecular pathology, diagnostics, and therapeutics

B Adejuyigbe, J Kallini, D Chiou, JR Kallini - International journal of …, 2023 - mdpi.com
Osteoporosis is a major public health concern affecting millions of people worldwide and
resulting in significant economic costs. The condition is characterized by changes in bone …