Potentials of natural antioxidants from plants as antiosteoporotic agents

E Sakai, F Farhana, Y Yamaguchi, T Tsukuba - Studies in Natural Products …, 2022 - Elsevier
In osteoporosis, the density and quality of bone are reduced and become more fragile, with
a significantly increased risk of fracture. Living tissue of bone undergoes continuous …

The underlying pathophysiology and therapeutic approaches for osteoporosis

H Awasthi, D Mani, D Singh… - Medicinal research …, 2018 - Wiley Online Library
With an increase in the ageing population worldwide, the prevalence of osteoporosis
increases at an alarming rate in both male and female irrespective of their ethnicity. At …

[PDF][PDF] Pharmacogenomics of osteoporosis: opportunities and challenges

TV Nguyen, JA Eisman - Journal of Musculoskeletal and Neuronal …, 2006 - ismni.org
Background Osteoporosis, the most common and serious skeletal" disease", is highly
prevalent among the elderly of both sexes, with a combined lifetime risk for hip fracture …

The role of flavonoids in the osteogenic differentiation of mesenchymal stem cells

J Zhang, Z Liu, Y Luo, X Li, G Huang, H Chen… - Frontiers in …, 2022 - frontiersin.org
Mesenchymal stem cells (MSCs) play an important role in developing bone tissue
engineered constructs due to their osteogenic and chondrogenic differentiation potential …

Vitamin E as an Antiosteoporotic Agent via Receptor Activator of Nuclear Factor Kappa‐B Ligand Signaling Disruption: Current Evidence and Other Potential …

KY Chin, S Ima-Nirwana - Evidence‐Based Complementary …, 2012 - Wiley Online Library
Osteoporosis is a growing healthcare burden that affects the quality of life in the aging
population. Vitamin E is a potential prophylactic agent that can impede the progression of …

Isoflavone intervention and its impact on bone mineral density in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials

R Inpan, M Na Takuathung, W Sakuludomkan… - Osteoporosis …, 2024 - Springer
Due to estrogen deficiency, postmenopausal women may suffer from an imbalance in bone
metabolism that leads to bone fractures. Isoflavones, a type of phytoestrogen, have been …

Evolving roles of natural terpenoids from traditional Chinese medicine in the treatment of osteoporosis

Y Zhuo, M Li, Q Jiang, H Ke, Q Liang… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis (OP) is a systemic metabolic skeletal disease which can lead to reduction in
bone mass and increased risk of bone fracture due to the microstructural degradation …

A review on the molecular mechanisms of action of natural products in preventing bone diseases

IU Okagu, TPC Ezeorba, RN Aguchem… - International Journal of …, 2022 - mdpi.com
The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects
that include certain types of cancers and strokes, hence the ongoing quest for the discovery …

[HTML][HTML] A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri-and postmenopausal women

MNT Lambert, LM Hu, PB Jeppesen - The American journal of clinical …, 2017 - Elsevier
Background Age-related estrogen deficiency leads to accelerated bone resorption. There is
evidence that, through selective estrogen receptor modulation, isoflavones may exert …

Effects of 6‐Hydroxyflavone on Osteoblast Differentiation in MC3T3‐E1 Cells

CH Lai, YW Wu, SD Yeh, YH Lin… - … and Alternative Medicine, 2014 - Wiley Online Library
Osteoblast differentiation plays an essential role in bone integrity. Isoflavones and some
flavonoids are reported to have osteogenic activity and potentially possess the ability to treat …