Increased intracellular generation of reactive oxygen species [ROS] has been implicated in
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …

In type 2 diabetes, metabolic stress has a negative impact on pancreatic β-cell function and
survival (T2D). Although the pathogenesis of metabolic stress is complex, an imbalance in …

Oxidative stress has been linked to the pathogenesis of the major complications of diabetes
in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a …

Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …

In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …

Several molecular mechanisms have been identified that mediate the tissue-damaging
effects of hyperglycemia. These are increased flux through the polyol and hexosamine …

It is well established that glucotoxicity (caused by high glucose concentrations; HG)
underlies pathogenesis of islet dysfunction in diabetes. We have recently demonstrated that …

It has been proposed that pancreatic beta-cell dysfunction in type 2 diabetes is promoted by
oxidative stress caused by NADPH oxidase (Nox) over-activity. The aim of the present study …

Predictions of diabetes prevalence over the next decades warrant the aggressive discovery
of new approaches to stop or reverse loss of functional beta cell mass. Beta cells are …

Aims: Nicotinamide adenine dinucleotide phosphate oxidases (NOX-es) produce reactive
oxygen species and modulate β-cell insulin secretion. Islets of type 2 diabetic subjects …