Alleviation of hepatic steatosis: Dithizone-related gut microbiome restoration during paneth cell dysfunction

S Zhang, HM Tun, D Zhang, HT Chau… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the world's most common chronic liver disease, is
increasingly linked to gut dysbiosis. Paneth cells secrete antimicrobial peptides that regulate …

Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid

W Wei, CC Wong, Z Jia, W Liu, C Liu, F Ji, Y Pan… - Nature …, 2023 - nature.com
Non-alcoholic steatohepatitis (NASH) is the severe form of non-alcoholic fatty liver disease,
and is characterized by liver inflammation and fat accumulation. Dietary interventions, such …

Bacteroides thetaiotaomicron ameliorates mouse hepatic steatosis through regulating gut microbial composition, gut-liver folate and unsaturated fatty acids …

H Li, XK Wang, M Tang, L Lei, JR Li, H Sun, J Jiang… - Gut …, 2024 - Taylor & Francis
Gut microbiota plays an essential role in the progression of nonalcoholic fatty liver disease
(NAFLD), making the gut-liver axis a potential therapeutic strategy. Bacteroides genus, the …

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

AWF Janssen, T Houben, S Katiraei, W Dijk… - Journal of lipid …, 2017 - ASBMB
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, yet
the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the …

Activation of a specific gut bacteroides-folate-liver axis benefits for the alleviation of nonalcoholic hepatic steatosis

S Qiao, L Bao, K Wang, S Sun, M Liao, C Liu, N Zhou… - Cell Reports, 2020 - cell.com
A beneficial gut Bacteroides-folate-liver pathway regulating lipid metabolism is
demonstrated. Oral administration of a Ganoderma meroterpene derivative (GMD) …

Oral pathobiont-induced changes in gut microbiota aggravate the pathology of nonalcoholic fatty liver disease in mice

K Yamazaki, T Kato, Y Tsuboi, E Miyauchi… - Frontiers in …, 2021 - frontiersin.org
Background & Aims Periodontitis increases the risk of nonalcoholic fatty liver disease
(NAFLD); however, the underlying mechanisms are unclear. Here, we show that gut …

[HTML][HTML] Equol, a metabolite of gut microbiota, attenuates liver steatosis via the SIRT1/HNF4α pathway in NAFLD mice

Z Luo, L Yang, J He, Y Han, X Rong, D Luo… - Journal of Functional …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a potentially severe liver disease that increases
evidence indicates that gut microbiota is related to it. In the study, 16S rRNA sequencing …

Microbial metabolites: critical regulators in NAFLD

X Dai, H Hou, W Zhang, T Liu, Y Li, S Wang… - Frontiers in …, 2020 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
throughout the world. The relationship between gut microbiota and NAFLD has been …

Ileal bile acid transporter inhibitor improves hepatic steatosis by ameliorating gut microbiota dysbiosis in NAFLD model mice

M Matsui, S Fukunishi, T Nakano, T Ueno, K Higuchi… - MBio, 2021 - Am Soc Microbiol
Nonalcoholic fatty liver disease (NAFLD), characterized by excessive fat deposition in the
liver unrelated to alcohol consumption, is highly prevalent worldwide. However, effective …

Diosgenin ameliorates non-alcoholic fatty liver disease by modulating the gut microbiota and related lipid/amino acid metabolism in high fat diet-fed rats

Y Zhou, R Li, Y Zheng, M Song, S Zhang… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease closely associated with
dietary habits. Diosgenin is abundant in yam, a common food and traditional Chinese …