Isoprenoids play important roles in all living organisms as components of structural
cholesterol, steroid hormones in mammals, carotenoids in plants, and ubiquinones …

The development of new drugs is one strategy for malaria control. Biochemical pathways
localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are …

Background Isoprenoids are the most diverse and abundant group of natural products. In
Plasmodium falciparum, isoprenoid synthesis proceeds through the methyl erythritol …

Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium
falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via …

The putative catalytic domain of an open reading frame from Plasmodium falciparum with
similarity to the ispF gene of Escherichia coli specifying 2C‐methyl‐d‐erythritol 2, 4 …

In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl
diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the …

Two genes encoding the enzymes 1-deoxy-d-xylulose-5-phosphate synthase and 1-deoxy-d-
xylulose-5-phosphate reductoisomerase have been recently identified, suggesting that …

We present here a study of a eukaryotic trans-prenylsynthase from the malaria pathogen
Plasmodium vivax. Based on the results of biochemical assays and contrary to previous …

The bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key
branchpoint enzyme in isoprenoid biosynthesis in Plasmodium falciparum (malaria) …

Synthesis of farnesyl pyrophosphate (FPP), a key intermediate of the isoprenoid
biosynthesis pathway, is catalyzed by FPP synthase (FPPS). Antiprotozoal properties of …