Intracellular infections are tricky to treat, the reason being the poor penetration of antibiotics/
antimycotics into the microbial niche (host cell). Macrophages are primary targets of …

Infectious diseases caused by diverse intracellular pathogens, such as viruses, some
bacteria, fungi and protozoan parasites are major health threats worldwide. Particularly …

Macrophages have been extensively used in the development of drug delivery systems, as
they can prolong the circulation and release of drugs, extend their half-life, increase their …

Introduction: Targeted drug delivery to the macrophages appears to be an attractive
proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be …

Although vaccines and antibiotics could kill or inhibit microbes, many infectious diseases
remain difficult to treat because of acquired resistance and adverse side effects. Nano …

Since their introduction into the therapeutic world, antimicrobial agents have raised the
health status of the population worldwide. Frequent use of antimicrobial agents has reduced …

Microorganisms, such as bacteria, viruses, and fungi, can cause infectious diseases. Among
these, bacteria are the most important cause of infection-associated death in children, the …

In the field of antibiotherapy, intracellular infections remain difficult to eradicate mainly due to
the poor intracellular penetration of most of the commonly used antibiotics. Bacteria have …

The barrier function of host cells enables intracellular bacteria to evade the lethality of the
host immune system and antibiotics, thereby causing chronic and recurrent infections that …

Biodegradable nanoparticles have emerged as a promising strategy for ferrying
antimicrobial agents into specific cells due to their unique properties. This review discusses …