[HTML][HTML] Intersectin scaffold proteins and their role in cell signaling and endocytosis
E Herrero-Garcia, JP O'Bryan - … et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
Intersectins (ITSNs) are a family of multi-domain proteins involved in regulation of diverse
cellular pathways. These scaffold proteins are well known for regulating endocytosis but …
cellular pathways. These scaffold proteins are well known for regulating endocytosis but …
Intersectin—many facets of a scaffold protein
M Mintoo, V Rajagopalan… - Biochemical Society …, 2024 - portlandpress.com
Intersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions
including regulation of endocytosis, vesicle transport, and activation of various signal …
including regulation of endocytosis, vesicle transport, and activation of various signal …
[HTML][HTML] Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways
MP Hunter, A Russo, JP O'Bryan - International journal of molecular …, 2013 - mdpi.com
Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate
endocytosis and cell signaling. ITSN genes are highly conserved and present in all …
endocytosis and cell signaling. ITSN genes are highly conserved and present in all …
Intersecting pathways in cell biology
JP O'Bryan - Science signaling, 2010 - science.org
The endocytic pathway is involved in activation and inhibition of cellular signaling. Thus,
defining the regulatory mechanisms that link endocytosis and cellular signaling is of interest …
defining the regulatory mechanisms that link endocytosis and cellular signaling is of interest …
Intersectin multidomain adaptor proteins: regulation of functional diversity
Adaptor/scaffold proteins serve as platforms for the assembly of multiprotein complexes and
regulate the efficiency and specificity of signalling cascades. Intersectins (ITSNs) are an …
regulate the efficiency and specificity of signalling cascades. Intersectins (ITSNs) are an …
Intersectin1‐s, A multidomain adapter protein, Is essential for malignant glioma proliferation
F Gu, H Zhang, F Qin, X Liu, W Li, L Fu, G Ying, B Li… - Glia, 2015 - Wiley Online Library
Glioblastomas, the most aggressive form of primary brain tumors with a tendency to invade
surrounding healthy brain tissues, remains an incurable disease. Intersectin (ITSN) is a …
surrounding healthy brain tissues, remains an incurable disease. Intersectin (ITSN) is a …
Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling
NP Martin, RP Mohney, S Dunn, M Das, E Scappini… - Molecular …, 2006 - ASPET
Receptor tyrosine kinases (RTKs) are critical for normal cell growth, differentiation, and
development, but they contribute to various pathological conditions when disrupted …
development, but they contribute to various pathological conditions when disrupted …
Regulation of neuron survival through an intersectin-phosphoinositide 3′-kinase C2β-AKT pathway
M Das, E Scappini, NP Martin, KA Wong… - … and cellular biology, 2007 - Taylor & Francis
While endocytosis attenuates signals from plasma membrane receptors, recent studies
suggest that endocytosis also serves as a platform for the compartmentalized activation of …
suggest that endocytosis also serves as a platform for the compartmentalized activation of …
[HTML][HTML] Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins
Background Scaffolding proteins of the intersectin (ITSN) family, ITSN1 and ITSN2, are
crucial for the initiation stage of clathrin-mediated endocytosis. These proteins are closely …
crucial for the initiation stage of clathrin-mediated endocytosis. These proteins are closely …
Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons
Intersectin 1 (ITSN1) is a conserved adaptor protein implicated in endocytosis, regulation of
actin cytoskeleton rearrangements and mitogenic signaling. Its expression is characterized …
actin cytoskeleton rearrangements and mitogenic signaling. Its expression is characterized …