Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic
stem cell activity. Somatic stem cells have to respond to tissue damage and proliferate …

Adult tissue homeostasis requires a tight balance between the removal of old or damaged
cells and the production of new ones. Such processes are usually driven by dedicated stem …

Drosophila has long been an excellent model organism for studying stem cell biology.
Notably, studies of Drosophila's germline stem cells have been instrumental in developing …

The gastrointestinal tract of complex metazoans is highly compartmentalized. It is lined by a
series of specialized epithelia that are regenerated by specific populations of stem cells. To …

Stem cells have essential functions in the development and maintenance of our organs.
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …

Maintenance of tissue homeostasis is critical in tissues with high turnover such as the
intestinal epithelium. The intestinal epithelium is under constant cellular assault due to its …

Many adult tissues and organs are maintained by resident stem cells that are activated in
response to injury but the mechanisms that regulate stem cell activity during regeneration …

Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly
replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of …

Coordination of stem cell activity with inflammatory responses is critical for regeneration and
homeostasis of barrier epithelia. The temporal sequence of cell interactions during injury …

Many tissues in higher animals undergo dynamic homeostatic growth, wherein damaged or
aged cells are replaced by the progeny of resident stem cells. To maintain homeostasis …