Nickel has been shown to be an essential trace element involved in the metabolism of
several species of bacteria, archea, and plants. In these organisms, nickel is involved in …

Nickel (II) compounds are established human carcinogens, but the molecular mechanisms
underlying their activity are only partially known. One mechanism may include mediation by …

Over the last years, we have been testing a hypothesis that molecular mechanisms of nickel-
induced carcinogenesis include interactions of this metal with major chromatin components; …

Nickel compounds are known human carcinogens, but the exact molecular mechanisms of
nickel carcinogenesis are not known. Due to their abundance, histones are likely targets for …

Metal Ions in Biological Systems is devoted to increasing our understanding of the
relationship between the chemistry of metals and life processes. The volumes reflect the …

A combined pH-metric and spectroscopic (UV/vis, CD, NMR) study of the Ni (II) binding to
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a …

Ni (II) compounds are well known as human carcinogens, though the molecular events
which are responsible for this are not yet fully understood. It has been proposed that the …

Studies of 2 '-deoxyguanosine oxidation by hydrogen peroxide in the presence of CH3CO-
Cys-Ala-Ile-His-NH2 (CAIH) and/or NiCl2 have been carried out in 100 mM phosphate buffer …

Following the discovery of the first specific and essential role of nickel in biology in 1975 (the
dinuclear active site of the enzyme urease)[1], nickel has become a major player in …

Water-insoluble nickel compounds tend to be carcinogenic because they enter cells through
phagocytosis. Highly water-soluble nickel salts, such as nickel chloride, do not enter cells …