In recent years, bone regeneration has emerged as a remarkable field that offers promising
guidance for treating bone-related diseases, such as bone defects, bone infections, and …

The repair of large bone defects remains a huge challenge for bone regenerative medicine.
To meet this challenge, a number of bone substitutes have been developed over recent …

The paradigm of metallic ions as exclusive toxic agents is changing. During the last 60
years, knowledge about toxicological and immunological reactions to metal particles and …

Large-sized bone defects are a great challenge in clinics and considerably impair the quality
of patients' daily life. Tissue engineering strategies using cells, scaffolds, and bioactive …

Mineral ions play a crucial role in various biological processes in the human body,
particularly in bone repair and regeneration. Supplementation with mineral ions offers …

While bone tissue is known for its inherent regenerative abilities, various pathological
conditions and trauma can disrupt its meticulously regulated processes of bone formation …

The treatment of bone defects is an important problem in clinical practice. The rapid
development of bone tissue engineering (BTE) may provide a new method for bone defect …

Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic
capability to regenerate upon injury, several pathologies and injuries could hamper the …

The regeneration of bone tissue is the main purpose of most therapies in dental medicine.
For bone regeneration, calcium phosphate (CaP)-based substitute materials based on …

Highlights•Alternative bone regenerative therapeutics are needed.•Ions have been
proposed to regenerate skeletal tissue.•Drug delivery systems have been studied to deliver …