Background The inflammatory myeloid cell activation is one of the hallmarks of experimental
autoimmune encephalomyelitis (EAE), yet the in vivo role of the inflammatory myeloid cell …

Background Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease
characterized by motor deficits and cognitive decline. Many immune aspects of the disease …

In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
(MS), peripherally developed myelin-reactive T lymphocytes stimulate myeloid cells (ie …

Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) deposits and
microglia-dominated inflammatory activation. Innate immune signaling controls microglial …

Loss of IκB kinase (IKK) β-dependent NF-κB signaling in hematopoietic cells is associated
with increased granulopoiesis. Here we identify a regulatory cytokine loop that causes …

The NF-κB family of transcription factors plays a pivotal role in T cell activation and survival
during (auto) immune responses. IκB kinase 2/β (IKK2) is part of the IκB kinase complex, a …

Traumatic spinal cord injury (SCI) is followed by massive infiltration and activation of myeloid
cells such as neutrophils and macrophages, but the functions of these cells are …

NF-κB is a key player in inflammatory diseases, including multiple sclerosis (MS) and its
animal model, experimental autoimmune encephalomyelitis (EAE). However, the effects of …

The nuclear IκB family protein IκBNS is expressed in T cells and plays an important role in
Interferon (IFN)-γ and Interleukin (IL)-2 production. IκB-ζ, the most similar homolog of IκBNS …

Activation of transcription factor NF-κB in the central nervous system (CNS) has been linked
to autoimmune demyelinating disease; however, it remains unclear whether its function is …