IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and …
Background The inflammatory myeloid cell activation is one of the hallmarks of experimental
autoimmune encephalomyelitis (EAE), yet the in vivo role of the inflammatory myeloid cell …
autoimmune encephalomyelitis (EAE), yet the in vivo role of the inflammatory myeloid cell …
IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
M Avloniti, M Evangelidou, M Gomini, T Loupis… - Journal of …, 2024 - Springer
Background Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease
characterized by motor deficits and cognitive decline. Many immune aspects of the disease …
characterized by motor deficits and cognitive decline. Many immune aspects of the disease …
[HTML][HTML] Deficiency of IκB kinase β in myeloid cells reduces severity of experimental autoimmune encephalomyelitis
W Hao, Y Decker, L Schnöder, A Schottek, D Li… - The American Journal of …, 2016 - Elsevier
In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
(MS), peripherally developed myelin-reactive T lymphocytes stimulate myeloid cells (ie …
(MS), peripherally developed myelin-reactive T lymphocytes stimulate myeloid cells (ie …
IKKβ deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology
Y Liu, X Liu, W Hao, Y Decker… - Journal of …, 2014 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) deposits and
microglia-dominated inflammatory activation. Innate immune signaling controls microglial …
microglia-dominated inflammatory activation. Innate immune signaling controls microglial …
TNF-α–dependent loss of IKKβ-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis
AK Mankan, O Canli, S Schwitalla… - Proceedings of the …, 2011 - National Acad Sciences
Loss of IκB kinase (IKK) β-dependent NF-κB signaling in hematopoietic cells is associated
with increased granulopoiesis. Here we identify a regulatory cytokine loop that causes …
with increased granulopoiesis. Here we identify a regulatory cytokine loop that causes …
IκB kinase 2/β deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis
B Greve, R Weissert, N Hamdi, E Bettelli… - The Journal of …, 2007 - journals.aai.org
The NF-κB family of transcription factors plays a pivotal role in T cell activation and survival
during (auto) immune responses. IκB kinase 2/β (IKK2) is part of the IκB kinase complex, a …
during (auto) immune responses. IκB kinase 2/β (IKK2) is part of the IκB kinase complex, a …
IKK‐β‐mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury
J Kang, MH Jiang, HJ Min, EK Jo, S Lee… - European journal of …, 2011 - Wiley Online Library
Traumatic spinal cord injury (SCI) is followed by massive infiltration and activation of myeloid
cells such as neutrophils and macrophages, but the functions of these cells are …
cells such as neutrophils and macrophages, but the functions of these cells are …
NF-κB activation protects oligodendrocytes against inflammation
S Stone, S Jamison, Y Yue, W Durose… - Journal of …, 2017 - Soc Neuroscience
NF-κB is a key player in inflammatory diseases, including multiple sclerosis (MS) and its
animal model, experimental autoimmune encephalomyelitis (EAE). However, the effects of …
animal model, experimental autoimmune encephalomyelitis (EAE). However, the effects of …
The Nuclear IκB Family Protein IκBNS Influences the Susceptibility to Experimental Autoimmune Encephalomyelitis in a Murine Model
S Kobayashi, A Hara, T Isagawa, I Manabe, K Takeda… - PLoS …, 2014 - journals.plos.org
The nuclear IκB family protein IκBNS is expressed in T cells and plays an important role in
Interferon (IFN)-γ and Interleukin (IL)-2 production. IκB-ζ, the most similar homolog of IκBNS …
Interferon (IFN)-γ and Interleukin (IL)-2 production. IκB-ζ, the most similar homolog of IκBNS …
Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
G van Loo, R De Lorenzi, H Schmidt, M Huth… - Nature …, 2006 - nature.com
Activation of transcription factor NF-κB in the central nervous system (CNS) has been linked
to autoimmune demyelinating disease; however, it remains unclear whether its function is …
to autoimmune demyelinating disease; however, it remains unclear whether its function is …