In a previous study, we found that the antinociceptive effect of IT-administered morphine on
the tail-flick (TF) reflex of rats was potentiated within 1 day after spinal transection. This …

This study was designed to determine if morphine administered intrathecally (IT) interacts
with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia …

The antinociceptive effect of intrathecal morphine on the tail-flick (TF) reflex of rats was
significantly enhanced within one day after spinal transaction (ED 50= 0.125 μg) relative to …

A controversy exists as to whether morphine attenuates spinal cord nociceptive transmission
through a supraspinal site of action. The approach of examining the effects of morphine on …

Hydroxytryptamine (5-HT) receptor blockade by administration of mianserin (1 mg/kg) or
metergoline (0.25 mg/kg) shortened the response latencies of rats in the hot-plate (hind-paw …

We examined the properties of the drug interaction between morphine and 5-HT3 receptor
antagonist at the spinal level. The nociceptive state was induced by subcutaneously …

It is documented that spinal nociceptive transmission receives descending facilitatory and
inhibitory modulation from supraspinal structures. The rostral ventral medulla (RVM) …

Nerve ligation injury in rats produces increased sensitivity and exaggerated responses to
nociceptive stimuli (hyperalgesia) as well as nociceptive responses to normally innocuous …

To examine the role of the descending serotonergic system in the regulation of spinal
nociceptive processing, the effects of serotonin (5-HT) and selective ligands for 5-HT …

The present study investigated the effect of systemically administered pentobarbital on the
tail-flick (TF) reflex in rats, the neurochemical mechanism of action and the role of …