Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice

ARS Santos, JB Calixto - Neuroscience letters, 1997 - Elsevier
This study investigates the antinociception caused by intradermal (id) or
intracerebroventricular (icv) injection of the capsaicin receptor antagonist capsazepine …

Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice

T Sakurada, T Matsumura, T Moriyama… - Pharmacology …, 2003 - Elsevier
Intraplantar injection of capsaicin (1.6 μg/paw) into the mouse hindpaw produced an acute
paw-licking/biting response. This study was designed (1) to investigate the antinociceptive …

Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw

A Dray, A Dickenson - Pain, 1991 - Elsevier
Systemic capsaicin and an analogue, olvanil (NE-19550, 4-hydroxy-3-methoxyphenyl
methyl-9Z-octadecenamide), were tested for antinociceptive activity in a model of persistent …

Roles of capsaicin-sensitive primary afferents in differential rat models of inflammatory pain: a systematic comparative study in conscious rats

HS Chen, X He, Y Wang, WW Wen, HJ You… - Experimental …, 2007 - Elsevier
To characterize the role of capsaicin-sensitive primary afferents in inflammatory pain, the
effects of subcutaneous (sc) injection of 0.15% capsaicin on different chemical irritants …

Ruthenium red blocks the capsaicin-induced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of …

A Dray, CA Forbes, GM Burgess - Neuroscience letters, 1990 - Elsevier
In a number of sensory neuron preparations, Ruthenium red (RR) selectively attenuated the
response to capsaicin. First, RR (100 nM) reversibly abolished capsaicin but not bradykinin …

Pharmacological characterization of the vanilloid receptor in the rat dorsal spinal cord

KA Wardle, J Ranson, GJ Sanger - British journal of …, 1997 - Wiley Online Library
In the present study a novel 96‐well plate assay system was used to characterize
pharmacologically the vanilloid receptor in the dorsal spinal cord of the rat. When activated …

Interaction between vanilloid and glutamate receptors in the central modulation of nociception

E Palazzo, V de Novellis, I Marabese, D Cuomo… - European journal of …, 2002 - Elsevier
This study investigates the effect of microinjections of capsaicin in the periaqueductal grey
matter of rats on nociceptive behaviour and the possible interactions with NMDA and mGlu …

[HTML][HTML] Pain behaviors produced by capsaicin: influence of inflammatory mediators and nerve injury

J Sawynok, A Reid, J Meisner - The Journal of Pain, 2006 - Elsevier
The present study was undertaken to characterize spontaneous (ie, nonevoked) pain
behaviors (flinching, biting/licking) produced by local injections of capsaicin into the rat …

Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic …

A Szallasi, S Nilsson, T Farkas-Szallasi, PM Blumberg… - Brain research, 1995 - Elsevier
Vanilloid (capsaicin) receptors were visualized by [3H] resiniferatoxin (RTX)
autoradiography in the brain of newborn as well as adult (both control and colchicine …

Vagal afferent stimulation-produced effects on nociception in capsaicin-treated rats

K Ren, M Zhuo, A Randich… - Journal of …, 1993 - journals.physiology.org
1. The effects of electrical stimulation of cervical vagal afferent fibers on the nociceptive tail-
flick (TF) reflex and responses of spinal dorsal horn neurons to noxious cutaneous …