Emergence of SARS-CoV-2 spike mutations during prolonged infection in immunocompromised hosts

KKK Ko, H Yingtaweesittikul, TT Tan… - Microbiology …, 2022 - Am Soc Microbiol
Immunocompromised hosts with prolonged severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infections have been implicated in the emergence of highly mutated SARS …

[HTML][HTML] SARS-CoV-2 variants, spike mutations and immune escape

WT Harvey, AM Carabelli, B Jackson… - Nature Reviews …, 2021 - nature.com
Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) genome are expected to be either deleterious and swiftly purged or relatively …

[HTML][HTML] SARS-CoV-2 mutations acquired during serial passage in human cell lines are consistent with several of those found in recent natural SARS-CoV-2 variants

H Chung, JY Noh, BS Koo, JJ Hong, HK Kim - Computational and Structural …, 2022 - Elsevier
Since the outbreak of coronavirus disease (COVID-19) in 2019, severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has evolved into diverse variants. Here, an early …

[HTML][HTML] SARS-COV-2 variants: differences and potential of immune evasion

SM Hirabara, TDA Serdan, R Gorjao… - Frontiers in cellular …, 2022 - frontiersin.org
The structural spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) plays an essential role in infection and is an important target for neutralizing …

[HTML][HTML] The rapid adaptation of SARS-CoV-2–rise of the variants: transmission and resistance

SM Soh, Y Kim, C Kim, US Jang, HR Lee - Journal of Microbiology, 2021 - Springer
The causative factor of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) is continuously mutating. Interestingly, identified mutations mainly occur in the spike …

[HTML][HTML] Emerging mutations in Nsp1 of SARS-CoV-2 and their effect on the structural stability

K Mou, F Mukhtar, MT Khan, DB Darwish, S Peng… - Pathogens, 2021 - mdpi.com
The genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes 16
non-structural (Nsp) and 4 structural proteins. Among the Nsps, Nsp1 inhibits host gene …

[HTML][HTML] Mutation D614G increases SARS-CoV-2 transmission

P Arora, S Pöhlmann, M Hoffmann - Signal transduction and targeted …, 2021 - nature.com
It has been unclear why SARS-CoV-2 with a D614G mutation in the spike protein became
dominant early in the COVID-19 pandemic. A recent study by Hou et al. published in …

[HTML][HTML] Variant-specific deleterious mutations in the SARS-CoV-2 genome reveal immune responses and potentials for prophylactic vaccine development

MA Islam, S Shahi, AA Marzan, MR Amin… - Frontiers in …, 2023 - frontiersin.org
Introduction: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has had a
disastrous effect worldwide during the previous three years due to widespread infections …

[HTML][HTML] Geographic and genomic distribution of SARS-CoV-2 mutations

D Mercatelli, FM Giorgi - Frontiers in microbiology, 2020 - frontiersin.org
The novel respiratory disease COVID-19 has reached the status of worldwide pandemic and
large efforts are currently being undertaken in molecularly characterizing the virus causing it …

[HTML][HTML] The development of SARS-CoV-2 variants: the gene makes the disease

R Perez-Gomez - Journal of developmental biology, 2021 - mdpi.com
A novel coronavirus (SARS-CoV-2) emerged towards the end of 2019 that caused a severe
respiratory disease in humans called COVID-19. It led to a pandemic with a high rate of …