Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol
deposition in arteries, but the mechanisms linking cholesterol accumulation in macrophage …

Most types of cells in the body have no or very limited capacity of catabolizing cholesterol, so
cholesterol efflux is essential for cholesterol homeostasis. There are multiple mechanisms …

Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol
deposition in arteries. Plasma high density lipoprotein (HDL) levels bear a strong …

Background—Two macrophage ABC transporters, ABCA1 and ABCG1, have a major role in
promoting cholesterol efflux from macrophages. Peritoneal macrophages deficient in …

Objective—Maintenance of cholesterol homeostasis in human macrophages is essential to
prevent foam cell formation. We evaluated the relative contribution of the ABCA1 and …

Cholesterol efflux is the first and rate-limiting step of reverse cholesterol transport (RCT) from
peripheric cells to the liver. The involvement of high-density lipoprotein (HDL) in RCT …

Foam cell formation due to excessive accumulation of cholesterol by macrophages is a
pathological hallmark of atherosclerosis. Macrophages cannot limit the uptake of cholesterol …

A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of
cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol …

Most types of cells in the body do not express the capability of catabolizing cholesterol, so
cholesterol efflux is essential for homeostasis. For instance, macrophages possess four …

Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type
I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular …