Background: Nobiletin (NOB), isolated from Citrus nobilis, has been reported to inhibit
cerebral ischemia/reperfusion (I/R) induced cell apoptosis in the brain. The mechanisms and …

There is cumulative evidence that the serine-threonine kinase Akt and its downstream
nuclear transcription factor CREB are involved in neuronal survival and protection. The Akt …

Background Post-ischemic oxidative stress and inflammation play pivotal roles in the
pathogenesis of ischemic stroke and may represent therapeutic targets. Nobiletin (NOB) has …

Nobiletin, a citrus polymethoxylated flavone, is reported to possess various pharmacological
activities such as anticancer, anti-inflammation, and antioxidant effects. Recently, nobiletin …

Background Demethylnobiletin (DN), with a variety of biological activities, is a polymethoxy‐
flavanone (PMF) found in citrus. In the present study, we explored the biological activities …

This study was designed to investigate the effect of w007B, a newly synthesized derivative of
honokiol, on MCAO reperfusion, and its therapeutic time window and related mechanisms in …

Nobiletin (NOB) possesses multiple pharmacological effects, but its anti-apoptotic property
has acquired a great deal of attention. Endoplasmic reticulum (ER) stress (ERS)-induced …

Background Stroke is regarded as one of the main health concerns globally, presenting with
high mortality and morbidity rates. Cerebral ischemic damage and infarction are critically …

Cerebral ischemia-reperfusion can activate several transcription factors and lead to
inflammatory reactions, which related to pattern recognition receptors with immune …

OBJECTIVE: The aim of this study was to investigate whether sodium butyrate (NaB)
attenuated cerebral ischemia-reperfusion injury (IRI) in mice by inhibiting JNK/STAT …