Previous studies appeared to indicate that CYP1B1 was not constitutively expressed in
mouse liver. In our laboratory, we demonstrated using aromatic hydrocarbon‐responsive …

It has been suggested that acenaphthylene(ACN), piperonyl butoxide (PBO) and other
methylenedioxyphenyl(benzodioxole) compounds can function as aromatic hydrocarbon …

The regulation of CYP1A1 and CYP1A2 isozymes by piperonyl butoxide (PBO) and
acenaphthylene (ACN) was studied in the liver of male C57BL/6 and DBA/2 mice. These two …

Studies have suggested that phenobarbital (PB) induces members of the CYP1A subfamily
by both transcriptional and post-transcriptional mechanisms. Using the Ahr−/− mice, we …

The human CYP4B1 protein was expressed in the liver of a transgenic mouse line under the
control of the promoter of the human apolipoprotein E (apo E) gene. Hepatic microsomes of …

Tissue-specific induction of mRNA of cytochrome P450 (P450 or CYP) 1A1 and 1B1 by
polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) was …

The effects of phenobarbital treatment on the expression of the cytochrome P-450 (CYP or P-
450) enzyme CYP1A2 in the livers of mice of various strains were examined. Phenobarbital …

In mammals, the induction of experimental porphyria by halogenated aromatic hydrocarbons
(HAHs) seems to be influenced by the levels of hepatic CYP1A2. The pharmacokinetics and …

The scope of this study was to compare in vitro and in vivo cytochrome P450 (CYP) gene
induction in mice, using liver slices as an in vitro model. We have chosen to study mice to be …

The cytochrome P4501A (CYP1A) enzymes play important roles in the metabolic activation
and detoxification of numerous environmental carcinogens, including polycyclic aromatic …