Canine intestines possess similarities in anatomy, microbiology, and physiology to those of
humans, and dogs naturally develop spontaneous intestinal disorders similar to humans …

Canine intestines possess similarities in anatomy, microbiology, and physiology to those of
humans, and dogs naturally develop spontaneous intestinal disorders similar to humans …

The establishment of a three-dimensional (3D) epithelial structure and cytodifferentiation in
vitro is necessary to recapitulate in vivo-relevant structure and function of the human …

Standard two/three dimensional (2D/3D)-cell culture platforms have facilitated the
understanding of the communications between various cell types and their …

The intestinal epithelium has one of the highest turnover rates in the human body, which is
supported by intestinal stem cells. Culture models of intestinal physiology have been …

Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …

Intestinal organoids are increasingly being used to study the gut epithelium for digestive
disease modeling, or to investigate interactions with drugs, nutrients, metabolites …

Microfluidic technologies have been extensively investigated in recent years for developing
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …

Much of our understanding of molecular mecha-nisms of diseases has relied historically on
work performed in cancer cell lines. Although cancer-derived cell lines offer many …

Advancing knowledge of gastrointestinal physiology and its diseases critically depends on
the development of precise, species-specific in vitro models that faithfully mimic in vivo …