Fertility and infertility: genetic contributions from the hypothalamic-pituitary-gonadal axis

JC Achermann, JL Jameson - Molecular Endocrinology, 1999 - academic.oup.com
Infertility affects approximately 1 in 10 couples. Causes include physical, environmental, and
genetic factors, and both partners are equally likely to be affected. It is often difficult to …

[HTML][HTML] Molecular control of oogenesis

F Sánchez, J Smitz - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2012 - Elsevier
Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

The ovary: anatomy and function throughout human life

O Oktem, K Oktay - Annals of the New York academy of …, 2008 - Wiley Online Library
A prerequisite to the understanding of the ovarian diseases and infertility is a thorough
understanding of normal embryology and physiology of the ovary. Therefore, the objective of …

Oocyte maturation and embryonic failure

RM Moor, Y Dai, C Lee, J Fulka Jr - Human reproduction update, 1998 - academic.oup.com
Embryonic development is readily compromised by imperfections introduced during the
process of oocyte maturation. We discuss the nature and causes of these imperfections …

Genomewide discovery and classification of candidate ovarian fertility genes in the mouse

TD Gallardo, GB John, L Shirley, CM Contreras… - Genetics, 2007 - academic.oup.com
Female infertility syndromes are among the most prevalent chronic health disorders in
women, but their genetic basis remains unknown because of uncertainty regarding the …

The genetics of male infertility

V Mak, KA Jarvi - The Journal of urology, 1996 - Elsevier
PURPOSE: We provide an up-to-date summary of the genetic aspects of male infertility.
MATERIALS AND METHODS: The literature on male infertility was extensively reviewed …

[HTML][HTML] Contemporary genetic technologies and female reproduction

TEAREW Group, B Fauser, K Diedrich… - Human reproduction …, 2011 - ncbi.nlm.nih.gov
BACKGROUND The Fifth Evian Annual Reproduction (EVAR) Workshop Meeting discussed
knowledge regarding contemporary genetics in female reproduction. METHODS Specialist …

[PDF][PDF] Mammalian foetal ovarian development: consequences for health and disease

MA Sarraj, AE Drummond - Reproduction, 2012 - researchgate.net
The development of a normal ovary during foetal life is essential for the production and
ovulation of a high-quality oocyte in adult life. Early in embryogenesis, the primordial germ …

Oocyte-specific genes affect folliculogenesis, fertilization, and early development

P Zheng, J Dean - Seminars in reproductive medicine, 2007 - thieme-connect.com
Although cell-autonomous genetic programs pursued by germ and somatic cells are of
critical import, intimate interplays between the two cell types are also essential for normal …

Understanding the genetics of human infertility

Q Sang, PF Ray, L Wang - Science, 2023 - science.org
Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …