Abstract Annexin A5 (A5) forms 2-dimensional crystals over phospholipid bilayers, blocking
their availability for coagulation reactions. Recently, human antiphospholipid (aPL) …

The antiphospholipid (aPL) syndrome is an autoimmune condition that is marked by
recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have …

The phospholipid binding protein, annexin A5 (AnxA5), has potent anticoagulant properties
that result from its forming 2-dimensional crystals over phospholipids, blocking the …

Abstract Annexin A5 (AnxA5) is a potent anticoagulant protein that crystallizes over
phospholipid bilayers (PLBs), blocking their availability for coagulation reactions …

The paradoxical correlation between thrombosis and the lupus anticoagulant (LAC) effect is
an enigmatic feature of the antiphospholipid (aPL) syndrome. The Dutch authors previously …

Antiphospholipid (aPL) antibodies recognize receptor-bound β2 glycoprotein I (β2GPI) on
target cells, and induce an intracellular signaling and a procoagulant/proinflammatory …

Targeting of the annexin A5 anticoagulant shield may be a significant mechanism for
thrombosis and pregnancy losses in APS. This may occur via high affinity antibodies that …

Annexin A5 (AnxA5) binds to phospholipid bilayers, forming two-dimensional crystals that
block the phospholipids from availability for coagulation enzyme reactions. Antiphospholipid …

The association of thrombosis and gestational morbidity with antiphospholipid antibodies is
termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell …

Background: Annexin A5 is thought to have a role in the pathophysiology of the
antiphospholipid syndrome (APS)—a syndrome characterised by recurrent thrombosis and …