Background and methods: Host genomic alterations are closely related to dysfunction of
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …

With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …

GWAS, immune analyses and biomarker screenings have identified host factors associated
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …

Background Epigenome-wide association studies (EWAS) have identified CpG sites
associated with HIV infection in blood cells in bulk, which offer limited knowledge of cell-type …

Many complex diseases or traits are the results of both genetic and environmental factors.
The environmental factors affect the human body by modifying its epigenetics, which …

The molecular mechanisms underlying HIV-induced inflammation, which persists even
during effective long-term treatment, remain incompletely defined. Here, we studied …

The underlying mechanism of the HIV-1 reservoir, a major barrier to an HIV cure, is largely
unknown. The integration of HIV-1 DNA and immune defense mechanisms can disrupt the …

Background Human genetic variation—mostly in the human leukocyte antigen (HLA) and C–
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …

Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …

Background Previous epigenome-wide association studies have shown that HIV infection
can disrupt the host DNA methylation landscape. However, it remains unclear how …