Genome-wide characterization of host transcriptional and epigenetic alterations during HIV infection of T lymphocytes
X Zeng, JCC Tsui, M Shi, J Peng, CY Cao… - Frontiers in …, 2020 - frontiersin.org
Background and methods: Host genomic alterations are closely related to dysfunction of
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …
Deciphering DNA methylation in HIV infection
T Arumugam, U Ramphal, T Adimulam… - Frontiers in …, 2021 - frontiersin.org
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …
new global infections per year, it is imperative that we advance our understanding of all …
Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
B Oriol-Tordera, M Berdasco, A Llano, B Mothe… - PLoS …, 2020 - journals.plos.org
GWAS, immune analyses and biomarker screenings have identified host factors associated
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …
Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in …
X Zhang, Y Hu, RE Vandenhoudt, C Yan… - PLoS …, 2024 - journals.plos.org
Background Epigenome-wide association studies (EWAS) have identified CpG sites
associated with HIV infection in blood cells in bulk, which offer limited knowledge of cell-type …
associated with HIV infection in blood cells in bulk, which offer limited knowledge of cell-type …
HIV infection alters the human epigenetic landscape
Many complex diseases or traits are the results of both genetic and environmental factors.
The environmental factors affect the human body by modifying its epigenetics, which …
The environmental factors affect the human body by modifying its epigenetics, which …
DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4+ T cells in response to SIV infections
The molecular mechanisms underlying HIV-induced inflammation, which persists even
during effective long-term treatment, remain incompletely defined. Here, we studied …
during effective long-term treatment, remain incompletely defined. Here, we studied …
Epigenome-wide characterization reveals aberrant DNA methylation of host genes regulating CD4+ T cell HIV-1 reservoir size in women with HIV
The underlying mechanism of the HIV-1 reservoir, a major barrier to an HIV cure, is largely
unknown. The integration of HIV-1 DNA and immune defense mechanisms can disrupt the …
unknown. The integration of HIV-1 DNA and immune defense mechanisms can disrupt the …
The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With …
S Moron-Lopez, V Urrea, J Dalmau… - Clinical Infectious …, 2021 - academic.oup.com
Background Human genetic variation—mostly in the human leukocyte antigen (HLA) and C–
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …
Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns
A Esteban-Cantos, J Rodríguez-Centeno, JC Silla… - …, 2023 - thelancet.com
Background Previous epigenome-wide association studies have shown that HIV infection
can disrupt the host DNA methylation landscape. However, it remains unclear how …
can disrupt the host DNA methylation landscape. However, it remains unclear how …