Adeno-associated virus (AAV) vectors have become an important tool for delivering
therapeutic genes for a wide range of neurological diseases. AAV serotypes possess …

Adeno-associated viral (AAV) vectors have become the primary delivery agent for somatic
gene transfer into the central nervous system (CNS). To date, AAV-mediated gene delivery …

Vectors derived from adeno-associated virus (AAV) are promising candidates for neural cell
transduction in vivo because they are nonpathogenic and achieve long-term transduction in …

Adeno-associated viruses (AAVs) have become highly promising tools for research and
clinical applications in the central nervous system (CNS). However, specific delivery of …

A wide diversity of adeno-associated virus (AAV) structural proteins uncovered from latent
genomes in primate tissue has expanded the number of AAV vector serotypes, which can …

Several neurodevelopmental and neurodegenerative disorders affecting the central nervous
system are potentially treatable via viral vector-mediated gene transfer. Adeno-associated …

Recombinant Adeno-associated virus vectors (rAAV) are widely used for gene delivery and
multiple naturally occurring serotypes have been harnessed to target cells in different …

Canine models have many advantages for evaluating therapy of human central nervous
system (CNS) diseases. In contrast to nonhuman primate models, naturally occurring canine …

The safety and high efficiency of adeno-associated virus (AAV) vectors has facilitated their
wide-scale use to deliver therapeutic genes for experimental and clinical purposes in …

The brain parenchyma consists of several different cell types, such as neurones, astrocytes,
microglia, oligodendroglia and epithelial cells, which are morphologically and functionally …