BACKGROUND: The number of mouse mutants and strains with neural tube closure defects
(NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes …

Neural tube defects (NTDs) are severe congenital malformations affecting 1–2 in 1,000 live
births, whose etiology is multifactorial, involving environmental and genetic factors. NTDs …

Neural Tube Defects (NTDs) are congenital malformations that involve failure of the neural
tube closure during the early phases of development at any level of the rostro‐caudal axis …

Neural tube closure defects (NTDs), in particular anencephaly and spina bifida, are common
human birth defects (1 in 1000), their genetics is complex and their risk is reduced by …

Kibar Z, Salem S, Bosoi CM, Pauwels E, De Marco P, Merello E, Bassuk AG, Capra V, Gros
P. Contribution of VANGL2 mutations to isolated neural tube defects. Vangl2 was identified …

BACKGROUND Neural tube closure is a critical embryological process that requires the
coordination of many molecular and cellular events. Only recently has the molecular basis of …

It has been estimated that 60–70% of neural tube defects (NTDs) have a genetic component,
but few causative genes have been identified. The lack of information on genes associated …

Background Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes
have been shown to cause neural tube defects (NTDs) through the disruption of normal …

Neural tube defects (NTDs) is a general term for central nervous system malformations
secondary to a failure of closure or development of the neural tube. The resulting …

Neural tube defects (NTDs) represent a failure of the neural plate to complete the
developmental transition to a neural tube. NTDs are the most common birth anomaly of the …