Genetic, epigenetic, and environmental contributions to neural tube closure

JJ Wilde, JR Petersen, L Niswander - Annual review of genetics, 2014 - annualreviews.org
The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Exploring gene—gene interactions in the etiology of neural tube defects

LD Botto, P Mastroiacovo - Clinical genetics, 1998 - Wiley Online Library
The role of susceptibility genes in the etiology of birth defects is unclear, but may involve in
some cases multiple alleles at multiple loci. We suggest a simple epidemiologic approach to …

Roles of planar cell polarity pathways in the development of neutral tube defects

G Wu, X Huang, Y Hua, D Mu - Journal of biomedical science, 2011 - Springer
Neural tube defects (NTDs) are the second most common birth defect in humans. Despite
many advances in the understanding of NTDs and the identification of many genes related …

A genetic risk factor for mouse neural tube defects: defining the embryonic basis

A Fleming, AJ Copp - Human molecular genetics, 2000 - academic.oup.com
Genetic polymorphisms are thought to play an important role in determining susceptibility to
neural tube defects (NTDs), for example between different ethnic groups, but the embryonic …

Crooked tail (Cd) models human folate-responsive neural tube defects

M Carter, S Ulrich, Y Oofuji, DA Williams… - Human molecular …, 1999 - academic.oup.com
Genetic correlation of human neural tube defects (NTDs) with NTD genes identified in
mouse may unravel predisposing complex traits for assessment of individual risk and …

Expanding the mutational spectrum associated to neural tube defects: Literature revision and description of novel VANGL1 mutations

E Merello, S Mascelli, A Raso, G Piatelli… - … Research Part A …, 2015 - Wiley Online Library
Background Neural Tube Defects (NTD) are a common class of birth defects that occur in
approximately 1 in 1000 live births. Both genetic and nongenetic factors are involved in the …

Digenic variants of planar cell polarity genes in human neural tube defect patients

L Wang, Y Xiao, T Tian, L Jin, Y Lei, RH Finnell… - Molecular genetics and …, 2018 - Elsevier
Neural tube defects (NTDs) are considered to be a complex genetic disorder, although the
identity of the genetic factors remains largely unknown. Mouse model studies suggest a …

Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis

R Allache, P De Marco, E Merello… - … Research Part A …, 2012 - Wiley Online Library
BACKGROUND Neural tube defects (NTDs), including anencephaly and spina bifida, have
a complex etiology. Defects in the planar cell polarity (PCP) signaling pathway have been …

Whole genomewide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10

E Rampersaud, AG Bassuk, DS Enterline… - Journal of medical …, 2005 - jmg.bmj.com
Neural tube defects (NTDs) are the second most common birth defects (1 in 1000 live births)
in the world. Periconceptional maternal folate supplementation reduces NTD risk by 50 …

Etiology, pathogenesis and prevention of neural tube defects

R Padmanabhan - Congenital anomalies, 2006 - Wiley Online Library
Spina bifida, anencephaly, and encephalocele are commonly grouped together and termed
neural tube defects (NTD). Failure of closure of the neural tube during development results …